Emerging viral infections relevant to transfusion medicine

Emerging viral infections relevant to transfusion medicine The development of new technologies leads to the discovery of new viruses. For each of these new infectious agents relevance to transfusion needs to be assessed. The questions to be answered are transmissibility by transfusion, pathogenicity, prevalence in blood donors, persistence and the availability of screening assays. Since 1995, three new viruses have been identified and extensively studied. GB virus-C/hepatitis G virus (GBV-C/HGV), a relatively rare virus with some homology with and epidemiological features of HCV, was thought to be related to post-transfusion hepatitis but was proven to be unrelated to hepatitis and is still in search of a disease. Human herpes virus-8 (HHV-8) is a major factor in the pathogenesis of Kaposi’s sarcoma and other tumours related to immunodeficiency. HHV-8 transmission by organ transplantation, but not by transfusion, has been demonstrated. The TT virus (TTV) is a ubiquitous virus infecting a very high proportion of humans in infancy. No clinical symptoms or pathogenicity is attached to TTV. To date, none of the emerging viruses have been proven relevant to transfusion. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Blood Reviews Elsevier

Emerging viral infections relevant to transfusion medicine

Blood Reviews, Volume 14 (4) – Dec 1, 2000

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Publisher
Elsevier
Copyright
Copyright © 2000 Elsevier Ltd
ISSN
0268-960X
eISSN
1532-1681
DOI
10.1054/blre.2000.0140
Publisher site
See Article on Publisher Site

Abstract

The development of new technologies leads to the discovery of new viruses. For each of these new infectious agents relevance to transfusion needs to be assessed. The questions to be answered are transmissibility by transfusion, pathogenicity, prevalence in blood donors, persistence and the availability of screening assays. Since 1995, three new viruses have been identified and extensively studied. GB virus-C/hepatitis G virus (GBV-C/HGV), a relatively rare virus with some homology with and epidemiological features of HCV, was thought to be related to post-transfusion hepatitis but was proven to be unrelated to hepatitis and is still in search of a disease. Human herpes virus-8 (HHV-8) is a major factor in the pathogenesis of Kaposi’s sarcoma and other tumours related to immunodeficiency. HHV-8 transmission by organ transplantation, but not by transfusion, has been demonstrated. The TT virus (TTV) is a ubiquitous virus infecting a very high proportion of humans in infancy. No clinical symptoms or pathogenicity is attached to TTV. To date, none of the emerging viruses have been proven relevant to transfusion.

Journal

Blood ReviewsElsevier

Published: Dec 1, 2000

References

  • A new variant of GB virus C/hepatitis G virus (GBV-C/HGV) from South Africa
    Sathar, M.A.; Soni, P.N.; Pegoraro, R.
  • Hepatitis G viral RNA in serum and in peripheral blood mononuclear cells and its relation to HCV-RNA in patients with clotting disorders
    Sheng, L.; Soumillion, A.; Peerlinck, K.
  • Transfusion-associated nosocomial hepatitis G virus infection in patients undergoing surgery
    Lunel, F.; Frangeul, L.; Chuteau, C.
  • Prevalence of GB virus type C/hepatitis G virus RNA and anti-E2 in individuals at high or low risk for blood-borne or sexually transmitted viruses: evidence of sexual and parenteral transmission
    Lefrere, J.J.; Roudot-Thoraval, F.; Morand-Joubert, L.
  • Route of TT virus infection in children
    Sugiyama, K.; Goto, K.; Ando, T.

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