Emerging role of extracellular vesicles as a senescence-associated secretory phenotype: Insights into the pathophysiology of lung diseases

Emerging role of extracellular vesicles as a senescence-associated secretory phenotype: Insights... Aging is a major risk factor for the development of chronic lung diseases such as chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and lung cancer. A main aspect of aging is the impaired function of maintaining homeostasis in the organs and body, which is associated with cellular senescence. Cellular senescence is recognized as the state of irreversible cell cycle arrest in response to a variety of cellular stresses. Senescent cells are not simply cell cycle-arrested cells; they also affect bystander cells through the secretion of bioactive molecules, termed the senescence-associated secretory phenotype (SASP). Many studies strongly indicate that senescent cells in the lungs are associated with the pathogenesis of age-related lung diseases by releasing SASP factors. Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, are released from almost all cell types and are recognized as important mediators of intercellular communication. They have been shown to carry and transfer a wide variety of molecules, such as microRNAs, messenger RNAs, DNA, and proteins, which can contribute to physiological functions and the pathology of various diseases. Increasing evidence suggests that EVs secreted from senescent cells have unique characteristics and contribute to modulating the phenotype of recipient cells similar to SASP factors. Thus, the EVs secreted from senescent cells, namely, senescence-associated EVs, appear to be a novel SASP factor. In this review, we summarize the current knowledge linking senescence-associated EVs to the SASP factor and discuss the roles of these EVs in age-related lung diseases. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Aspects of Medicine Elsevier

Emerging role of extracellular vesicles as a senescence-associated secretory phenotype: Insights into the pathophysiology of lung diseases

Loading next page...
 
/lp/elsevier/emerging-role-of-extracellular-vesicles-as-a-senescence-associated-YGKaRoTGz6
Publisher
Elsevier
Copyright
Copyright © 2017 The Authors
ISSN
0098-2997
eISSN
1872-9452
D.O.I.
10.1016/j.mam.2017.11.005
Publisher site
See Article on Publisher Site

Abstract

Aging is a major risk factor for the development of chronic lung diseases such as chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and lung cancer. A main aspect of aging is the impaired function of maintaining homeostasis in the organs and body, which is associated with cellular senescence. Cellular senescence is recognized as the state of irreversible cell cycle arrest in response to a variety of cellular stresses. Senescent cells are not simply cell cycle-arrested cells; they also affect bystander cells through the secretion of bioactive molecules, termed the senescence-associated secretory phenotype (SASP). Many studies strongly indicate that senescent cells in the lungs are associated with the pathogenesis of age-related lung diseases by releasing SASP factors. Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, are released from almost all cell types and are recognized as important mediators of intercellular communication. They have been shown to carry and transfer a wide variety of molecules, such as microRNAs, messenger RNAs, DNA, and proteins, which can contribute to physiological functions and the pathology of various diseases. Increasing evidence suggests that EVs secreted from senescent cells have unique characteristics and contribute to modulating the phenotype of recipient cells similar to SASP factors. Thus, the EVs secreted from senescent cells, namely, senescence-associated EVs, appear to be a novel SASP factor. In this review, we summarize the current knowledge linking senescence-associated EVs to the SASP factor and discuss the roles of these EVs in age-related lung diseases.

Journal

Molecular Aspects of MedicineElsevier

Published: Apr 1, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial