EMD 68843, a serotonin reuptake inhibitor with selective presynaptic 5-HT 1A receptor agonistic properties

EMD 68843, a serotonin reuptake inhibitor with selective presynaptic 5-HT 1A receptor agonistic... The 5-HT 1A receptor agonist 8-hydroxy-(di- n -propylamino)tetralin (8-OH-DPAT; 0.55 mg/kg s.c.) and the 5-HT (5-hydroxytryptamine, serotonin) reuptake inhibitor/5-HT 1A receptor ligand 5-{4-(4-(5-cyano-3-indolyl)-butyl)-1-piperazinyl}-benzofuran-2-carboxamide (EMD 68843; 55 mg/kg p.o.) inhibited ultrasonic vocalization in rats, an effect which was antagonized by the 5-HT 1A receptor antagonist N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)-ethyl)-N-(2-pyridyl)-cyclohexancarboxamide (WAY 100635; 1.0 mg/kg s.c.). 8-OH-DPAT decreased body temperature in rats, an effect which was also antagonized by WAY 100635, whereas EMD 68843 neither affected body temperature by itself nor interacted with 8-OH-DPAT or WAY 100635. The selective 5-HT reuptake inhibitor fluoxetine (100 mg/kg p.o.) had no effect on ultrasonic vocalization or body temperature. Therefore EMD 68843 is suggested to be a 5-HT 1A receptor agonist selective for presynaptic 5-HT 1A receptors. © 1997 Elsevier Science B.V. All rights reserved. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Pharmacology Elsevier

EMD 68843, a serotonin reuptake inhibitor with selective presynaptic 5-HT 1A receptor agonistic properties

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Publisher
Elsevier
Copyright
Copyright © 1997 Elsevier Science B.V.
ISSN
0014-2999
DOI
10.1016/S0014-2999(96)00999-5
Publisher site
See Article on Publisher Site

Abstract

The 5-HT 1A receptor agonist 8-hydroxy-(di- n -propylamino)tetralin (8-OH-DPAT; 0.55 mg/kg s.c.) and the 5-HT (5-hydroxytryptamine, serotonin) reuptake inhibitor/5-HT 1A receptor ligand 5-{4-(4-(5-cyano-3-indolyl)-butyl)-1-piperazinyl}-benzofuran-2-carboxamide (EMD 68843; 55 mg/kg p.o.) inhibited ultrasonic vocalization in rats, an effect which was antagonized by the 5-HT 1A receptor antagonist N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)-ethyl)-N-(2-pyridyl)-cyclohexancarboxamide (WAY 100635; 1.0 mg/kg s.c.). 8-OH-DPAT decreased body temperature in rats, an effect which was also antagonized by WAY 100635, whereas EMD 68843 neither affected body temperature by itself nor interacted with 8-OH-DPAT or WAY 100635. The selective 5-HT reuptake inhibitor fluoxetine (100 mg/kg p.o.) had no effect on ultrasonic vocalization or body temperature. Therefore EMD 68843 is suggested to be a 5-HT 1A receptor agonist selective for presynaptic 5-HT 1A receptors. © 1997 Elsevier Science B.V. All rights reserved.

Journal

European Journal of PharmacologyElsevier

Published: Mar 19, 1997

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