Elevated Neuropeptide Y Gene Expression and Release During Hypoglycemic Stress

Elevated Neuropeptide Y Gene Expression and Release During Hypoglycemic Stress Han, S. P., X. Chen, Y. M. Wu, L. Naes and T. C. Westfall. Elevated neuropeptide Y gene expression and release during hypoglycemic stress. Peptides 18(9) 1335–1340, 1997.—Our previous studies show that neuropeptide Y (NPY) is involved in mediating sympathetic nerve stimulation-induced vasoconstriction. Insulin hypoglycemia is known to produce increased sympathetic output and elevated arterial pressure. The present study examined the role of NPY in the hypertensive response to insulin by examining the effects of insulin on NPY gene expression, tissue content and release. Subcutaneous injection of insulin produced an immediate increase in plasma NPY immunoreactivity (NPYir) and delayed increases in adrenal and neuronal NPY mRNA and adrenal NPYir in rats. These results suggest that NPY may play a role in insulin-induced hypertension. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Peptides Elsevier

Elevated Neuropeptide Y Gene Expression and Release During Hypoglycemic Stress

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Publisher
Elsevier
Copyright
Copyright © 1997 Elsevier Science Inc.
ISSN
0196-9781
DOI
10.1016/S0196-9781(97)00212-X
Publisher site
See Article on Publisher Site

Abstract

Han, S. P., X. Chen, Y. M. Wu, L. Naes and T. C. Westfall. Elevated neuropeptide Y gene expression and release during hypoglycemic stress. Peptides 18(9) 1335–1340, 1997.—Our previous studies show that neuropeptide Y (NPY) is involved in mediating sympathetic nerve stimulation-induced vasoconstriction. Insulin hypoglycemia is known to produce increased sympathetic output and elevated arterial pressure. The present study examined the role of NPY in the hypertensive response to insulin by examining the effects of insulin on NPY gene expression, tissue content and release. Subcutaneous injection of insulin produced an immediate increase in plasma NPY immunoreactivity (NPYir) and delayed increases in adrenal and neuronal NPY mRNA and adrenal NPYir in rats. These results suggest that NPY may play a role in insulin-induced hypertension.

Journal

PeptidesElsevier

Published: Jan 1, 1997

References

  • Neuropeptide Y (NPY)
    Dahlof, C.; Dahlof, P.; Lundberg, J.M.
  • Hypothalamic control of adrenaline secretion in response to insufficient glucose
    Himsworth, R.L.
  • Neuropeptide Y and reserpine-resistant vasoconstriction evoked by sympathetic nerve stimulation in the dog skeletal muscle
    Pernow, J.; Kahan, T.; Lundberg, J.M.
  • Nerve fibers in the gut and pancreas of the rat displaying neuropeptide-Y immunoreactivity
    Sundler, F.; Moghimzadeh, E.; Hakanson, R.; Ekelund, M.; Emson, P.

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