Gene 731 (2020) 144352 Contents lists available at ScienceDirect Gene journal homepage: www.elsevier.com/locate/gene Research paper Elevated expression of IL-18 but not IL-1β gene is associated with NALP3 and AIM2 inﬂammasome in Polycystic Ovary Syndrome a,1 b,1 a,c b Maryam Rostamtabar , Sedighe Esmaeilzadeh , Ahmad Karkhah , Mania Amiri , a b b,c,d, Abolfazl Rahmani , Fatemeh Bakouei , Hamid Reza Nouri Student Research Committee, Babol University of Medical Sciences, Babol, Iran Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Science, Babol, Iran Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Immunoregulation Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran ARTIC L E I NF O ABSTRAC T Keywords: Inﬂammasome complex mediated interleukin 1β (IL-1β) and interleukin 18 (IL-18) production may be involved IL-1β in immunopathogenesis of polycystic ovary syndrome (PCOS). Therefore, this study was conducted to in- IL-18 vestigate involved inﬂammasome pathways in PCOS. Therefore, inﬂammasome genes expression and serum Inﬂammasome level of IL-1β were evaluated in 30 patients with conﬁrmed PCOS and 30 women without PCOS. A remarkable Polycystic Ovary Syndrome increase in expression of the nucleotide binding and oligomerization
Gene – Elsevier
Published: Mar 20, 2020
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