Elevated expression of IL-18 but not IL-1β gene is associated with NALP3 and AIM2 inflammasome in Polycystic Ovary Syndrome

Elevated expression of IL-18 but not IL-1β gene is associated with NALP3 and AIM2 inflammasome... Gene 731 (2020) 144352 Contents lists available at ScienceDirect Gene journal homepage: www.elsevier.com/locate/gene Research paper Elevated expression of IL-18 but not IL-1β gene is associated with NALP3 and AIM2 inflammasome in Polycystic Ovary Syndrome a,1 b,1 a,c b Maryam Rostamtabar , Sedighe Esmaeilzadeh , Ahmad Karkhah , Mania Amiri , a b b,c,d, Abolfazl Rahmani , Fatemeh Bakouei , Hamid Reza Nouri Student Research Committee, Babol University of Medical Sciences, Babol, Iran Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Science, Babol, Iran Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Immunoregulation Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran ARTIC L E I NF O ABSTRAC T Keywords: Inflammasome complex mediated interleukin 1β (IL-1β) and interleukin 18 (IL-18) production may be involved IL-1β in immunopathogenesis of polycystic ovary syndrome (PCOS). Therefore, this study was conducted to in- IL-18 vestigate involved inflammasome pathways in PCOS. Therefore, inflammasome genes expression and serum Inflammasome level of IL-1β were evaluated in 30 patients with confirmed PCOS and 30 women without PCOS. A remarkable Polycystic Ovary Syndrome increase in expression of the nucleotide binding and oligomerization http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Gene Elsevier

Elevated expression of IL-18 but not IL-1β gene is associated with NALP3 and AIM2 inflammasome in Polycystic Ovary Syndrome

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Publisher
Elsevier
Copyright
Copyright © 2020 Elsevier B.V.
ISSN
0378-1119
eISSN
1879-0038
DOI
10.1016/j.gene.2020.144352
Publisher site
See Article on Publisher Site

Abstract

Gene 731 (2020) 144352 Contents lists available at ScienceDirect Gene journal homepage: www.elsevier.com/locate/gene Research paper Elevated expression of IL-18 but not IL-1β gene is associated with NALP3 and AIM2 inflammasome in Polycystic Ovary Syndrome a,1 b,1 a,c b Maryam Rostamtabar , Sedighe Esmaeilzadeh , Ahmad Karkhah , Mania Amiri , a b b,c,d, Abolfazl Rahmani , Fatemeh Bakouei , Hamid Reza Nouri Student Research Committee, Babol University of Medical Sciences, Babol, Iran Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Science, Babol, Iran Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Immunoregulation Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran ARTIC L E I NF O ABSTRAC T Keywords: Inflammasome complex mediated interleukin 1β (IL-1β) and interleukin 18 (IL-18) production may be involved IL-1β in immunopathogenesis of polycystic ovary syndrome (PCOS). Therefore, this study was conducted to in- IL-18 vestigate involved inflammasome pathways in PCOS. Therefore, inflammasome genes expression and serum Inflammasome level of IL-1β were evaluated in 30 patients with confirmed PCOS and 30 women without PCOS. A remarkable Polycystic Ovary Syndrome increase in expression of the nucleotide binding and oligomerization

Journal

GeneElsevier

Published: Mar 20, 2020

References

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