Electrosprayed hydrophilic nanocomposites coated with shellac for colon-specific delayed drug delivery

Electrosprayed hydrophilic nanocomposites coated with shellac for colon-specific delayed drug... Advanced medicated nanomaterials that provide time- and target-specific drug release profiles are highly desired for efficacious drug delivery. In this study, a structural nanocomposite (P2) consisted of tamoxifen citrate (TC) and polyvinylpyrrolidone (PVP) (2:8, w:w) as core and shellac as shell was designed and fabricated using a modified coaxial electrospraying process. Shellac solution, which could not be converted into solid particles individually, was explored as a shell working fluid to encapsulate the core TC-PVP blending solution, which could be electrosprayed into solid particles (P1) all alone. SEM and TEM evaluations demonstrated that the quality of the core-shell particles P2 was higher than that of the monolithic particles P1 in terms of particle diameter, size distribution and number of satellites. XRD results suggested that TC was similarly present in an amorphous state in particles P1 and P2 due to its fine compatibility with PVP, which was verified through FTIR tests. In vitro dissolution experiments suggested that P2 could provide the designed drug colon-specific delayed release characteristics, passing through acidic conditions of pH2.0 dissolution media and freeing all of the loaded TC within 5min at pH7.4 dissolution media. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Materials & design Elsevier

Electrosprayed hydrophilic nanocomposites coated with shellac for colon-specific delayed drug delivery

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Ltd
ISSN
0264-1275
eISSN
0141-5530
D.O.I.
10.1016/j.matdes.2018.02.016
Publisher site
See Article on Publisher Site

Abstract

Advanced medicated nanomaterials that provide time- and target-specific drug release profiles are highly desired for efficacious drug delivery. In this study, a structural nanocomposite (P2) consisted of tamoxifen citrate (TC) and polyvinylpyrrolidone (PVP) (2:8, w:w) as core and shellac as shell was designed and fabricated using a modified coaxial electrospraying process. Shellac solution, which could not be converted into solid particles individually, was explored as a shell working fluid to encapsulate the core TC-PVP blending solution, which could be electrosprayed into solid particles (P1) all alone. SEM and TEM evaluations demonstrated that the quality of the core-shell particles P2 was higher than that of the monolithic particles P1 in terms of particle diameter, size distribution and number of satellites. XRD results suggested that TC was similarly present in an amorphous state in particles P1 and P2 due to its fine compatibility with PVP, which was verified through FTIR tests. In vitro dissolution experiments suggested that P2 could provide the designed drug colon-specific delayed release characteristics, passing through acidic conditions of pH2.0 dissolution media and freeing all of the loaded TC within 5min at pH7.4 dissolution media.

Journal

Materials & designElsevier

Published: Apr 5, 2018

References

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