Electroconvulsive shock increases tachykinin NK 1 receptors, but not the encoding mRNA, in rat cortex

Electroconvulsive shock increases tachykinin NK 1 receptors, but not the encoding mRNA, in rat... Recent studies have suggested that the substance P (tachykinin NK 1 ) receptor may be a pharmacological target for the treatment of mood disorders. Here, the effects of electroconvulsive shock on tachykinin NK 1 receptor gene expression in the rat brain was investigated. Rats received either a single electroconvulsive shock or five shocks on alternate days. Quantitative autoradiography with ( 125 I)Bolton Hunter-substance P, and in situ hybridisation histochemistry, were used to measure tachykinin NK 1 receptor-binding site densities and mRNA abundance, respectively. Densities of tachykinin NK 1 receptor-binding sites were significantly increased in the cerebral cortex following repeated electroconvulsive shock compared to sham treated animals. Densities remained unchanged in the hippocampus, striatum and amygdala. Neither single nor repeated electroconvulsive shock altered tachykinin NK 1 receptor mRNA in the brain regions examined. Hence, repeated electroconvulsive shock increases tachykinin NK 1 receptors in the rat brain in a regionally specific way. Upregulation of receptor-binding sites without a change in mRNA indicates that translational or post-translational mechanisms underlie this process. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Pharmacology Elsevier

Electroconvulsive shock increases tachykinin NK 1 receptors, but not the encoding mRNA, in rat cortex

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Publisher
Elsevier
Copyright
Copyright © 2001 Elsevier Ltd
ISSN
0014-2999
DOI
10.1016/S0014-2999(01)00777-4
Publisher site
See Article on Publisher Site

Abstract

Recent studies have suggested that the substance P (tachykinin NK 1 ) receptor may be a pharmacological target for the treatment of mood disorders. Here, the effects of electroconvulsive shock on tachykinin NK 1 receptor gene expression in the rat brain was investigated. Rats received either a single electroconvulsive shock or five shocks on alternate days. Quantitative autoradiography with ( 125 I)Bolton Hunter-substance P, and in situ hybridisation histochemistry, were used to measure tachykinin NK 1 receptor-binding site densities and mRNA abundance, respectively. Densities of tachykinin NK 1 receptor-binding sites were significantly increased in the cerebral cortex following repeated electroconvulsive shock compared to sham treated animals. Densities remained unchanged in the hippocampus, striatum and amygdala. Neither single nor repeated electroconvulsive shock altered tachykinin NK 1 receptor mRNA in the brain regions examined. Hence, repeated electroconvulsive shock increases tachykinin NK 1 receptors in the rat brain in a regionally specific way. Upregulation of receptor-binding sites without a change in mRNA indicates that translational or post-translational mechanisms underlie this process.

Journal

European Journal of PharmacologyElsevier

Published: Feb 16, 2001

References

  • Expression of 5-HT receptors and the 5-HT transporter in the rat brain after electroconvulsive shock
    Burnet, P.W.J; Sharp, T; LeCorre, S.M; Harrison, P.J
  • Reduction of substance P after chronic antidepressant treatment in the striatum, substantia nigra and amygdala of the rat
    Shirayama, Y; Mitsushio, H; Takashima, M; Ichikawa, H; Takahashi, K
  • Concurrent analysis of neuropeptides and biogenic amines in brain tissue of rats treated with electroconvulsive stimuli
    Stenfors, C; Bjellerup, P; Mathe, A.A; Theodorsson, E
  • Decreased levels of preprotachykinin-A and tachykinin NK 1 receptor mRNA in specific regions of the rat striatum after electroconvulsive stimuli
    Zachrisson, O; Mathe, A.A; Lindefors, N

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