Elastomers in vascular tissue engineering

Elastomers in vascular tissue engineering Available online at www.sciencedirect.com ScienceDirect 1,2 2 1,2,3 Matti A Hiob , Gareth W Crouch and Anthony S Weiss Elastomers are popular in vascular engineering applications, as material mechanically, control degradation to determine they offer the ability to design implants that match the implant lifespan, design signaling cues to promote bio- compliance of native tissue. By mimicking the natural tissue integration and ensure biocompatibility with the local environment, elastic materials are able to integrate within the environment are all critical in dictating the ultimate body to promote repair and avoid the adverse physiological success of a given implant. responses seen in rigid alternatives that often disrupt tissue function. The design of elastomers has continued to evolve, Synthetic elastomers moving from a focus on long term implants to temporary Polyurethanes resorbable implants that support tissue regeneration. This has Polyurethanes (PUs) are a broad group of copolymer been achieved through designing chemistries and processing materials composed of aliphatic or aromatic units linked methodologies that control material behavior and bioactivity, with polar urethane groups. PUs are synthesized through while maintaining biocompatibility in vivo. Here we review the the poly-addition of long chain polyols, di-isocyanates or latest developments in synthetic and natural elastomers http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Biotechnology Elsevier

Elastomers in vascular tissue engineering

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Publisher
Elsevier
Copyright
Copyright © 2016 Elsevier Ltd
ISSN
0958-1669
D.O.I.
10.1016/j.copbio.2016.04.008
Publisher site
See Article on Publisher Site

Abstract

Available online at www.sciencedirect.com ScienceDirect 1,2 2 1,2,3 Matti A Hiob , Gareth W Crouch and Anthony S Weiss Elastomers are popular in vascular engineering applications, as material mechanically, control degradation to determine they offer the ability to design implants that match the implant lifespan, design signaling cues to promote bio- compliance of native tissue. By mimicking the natural tissue integration and ensure biocompatibility with the local environment, elastic materials are able to integrate within the environment are all critical in dictating the ultimate body to promote repair and avoid the adverse physiological success of a given implant. responses seen in rigid alternatives that often disrupt tissue function. The design of elastomers has continued to evolve, Synthetic elastomers moving from a focus on long term implants to temporary Polyurethanes resorbable implants that support tissue regeneration. This has Polyurethanes (PUs) are a broad group of copolymer been achieved through designing chemistries and processing materials composed of aliphatic or aromatic units linked methodologies that control material behavior and bioactivity, with polar urethane groups. PUs are synthesized through while maintaining biocompatibility in vivo. Here we review the the poly-addition of long chain polyols, di-isocyanates or latest developments in synthetic and natural elastomers

Journal

Current Opinion in BiotechnologyElsevier

Published: Aug 1, 2016

References

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