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. AA serves as the precursor to various eicosanoids , which, in addition to AA itself, are capable of modulating uterine function. To examine whether PCBs stimulate phospholipase A2 (PLA2) to mobilize ...
and their modes of action on ‘extracellular’ phospholipid targets versus lipid mediator production . Phospholipase A2 (PLA2) catalyses the hydrolysis of the sn- 2 position of glycerophospholipids to yield (mostly ...
(Deutsch et al., 1997). The activity of phospholipase D (E.C. 3.1.4.4; PLD) was assayed in homogenates of uterine horns by measuring the release of [14C]ethanolamine from 1,2‐dioleoyl‐3‐phosphatidyl‐[ 2 ‐14C ...
are responsible for O2̄ generation and eicosanoid production . One PLA2 is a calcium-independent isoform that is activated by PCBs and causes the release of AA for activation of the NADPH oxidase. The other PLA2 ...
of LOX products may simply be a response to parturition since LOX products are released from critical intrauterine tissues in response to oxytocin (Pasetto et al., 1992), activation of protein kinase C ...
in amniotic fluid from pregnant women with labor [3], the detailed molecular mechanism underlying PGE2 production with labor remains largely unknown. Up-regulation of COX- 2 expression has been observed in fetal ...
production . Conceptuses and endometrial tissue samples (∼5 g) collected from five random sections along the mesometrial side of each uterine horn were placed into individual 1.5 mL of eppendorf tubes, flash ...
indicating premature labour. We identified expression of 15 genes in intrauterine tissues . The products of these genes are: PLA2G4A, a phospholipase responsible for release of the eicosanoid precursor ...
–regulated kinases 1/ 2 are activated (Bouaboula et al., 1995; Ibsen et al., 2017). Moreover, β-arrestins, Ca2+ channels, inward rectifying K+ currents and phospholipase C are modulated by cannabinoid receptor ...
gestation (7, 8). A larger-than-normal number of offspring triggers early-onset parturition due to premature stretch of uterine myometrial cells, activating the uterus to contract. The fetus and placenta also ...
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