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Metastases are the primary cause of death among cancer patients and efficacious new treatments are sorely needed. Targeted alpha-emitting radiopharmaceuticals that are highly cytotoxic may fulfill ...
available to deliver antigens into DCs during the ex vivo manipulation for further presentation to T cells in the recipient. DCs can be pulsed with synthetic peptide epitopes derived from known TAAs ...
hecate, an amphiphatic lytic peptide , synthetic analog of mellitin, the principal toxic component of natural honeybee venom, which was tethered with a 15 amino acid (81–95) fragment of hCGβ subunit ...
The advantages of synthetic peptides are that the preparations show chemical consistency from batch to batch and that immunological monitoring of defined T cell epitope is easier. Another advantage ...
(12). In addition, peptide -pulsed dendritic cells are being explored for the prevention and treatment of infectious diseases, such as acquired immunodeficiency syndrome (13,14), tuberculosis (15 ...
of treatment with the venom.32 2.1.2. Peptides targeting cancer cells Brachyin is a neurotoxin identified and characterized from venoms of the spider, Brachypelma albopilosum. There are six cysteines in its ...
results in animal models. Urological surgery The potential of gene therapy as a preventive strategy or adjunctive treatment for prostate adenocarcinoma120, bladder transitional carcinoma121 and renal cell ...
invasion was first recognized in 1925 when Fischer found that a lytic substance from sarcoma cells could degrade the fibrin stroma. Later it was found that the serine proteinase plasminogen activator (PA ...
than after treatment with placebo (117). This study is the first randomized trial supporting the use of MMP inhibitors in cancer treatment . Nonpeptidic MMP Inhibitors Problems with the peptidic MMP ...
peptide called SAMS peptide (HMRSAMSGLHLVKRR), AMP, and radiolabeled γ-32P-ATP [53]. We next evaluated the incorporation of radiolabeled phosphate from γ-32P-ATP into SAMS peptide . Compound C treatment ...
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