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Background: Early switch to oral antibacterials is recommended for the treatment of hospitalized patients with community -acquired pneumonia (CAP). However, its efficacy and safety in patients ...
to that of MOX in patients at risk of safety concerns. LEF is a promising new option for IV/ oral monotherapy of CABP in patients at risk of poor outcomes due to CABP or to antimicrobial therapy for CABP ...
(tx). LEF, a novel IV/ oral pleuromutilin, demonstrated efficacy / safety in noninferiority studies (LEAP 1/2) vs. MOX in adults with CABP. We report efficacy / safety of LEF in patients with LP based ...
was not designed to prove in a double-blind fashion that an early switch to oral therapy has the same efficacy as a full iv course. In accordance with a number of recent reviews 1,2,3,16 and a consensus statement ...
implementing guidelines Ramirez switch from intravenous use of intravenous and oral routes and for switch cephalosporin therapy early with to oral cefixime in to oral This is on use based the of therapy patients ...
Med. 1995;155(12):1273-12767778957PubMedGoogle ScholarCrossref 27. Castro-Guardiola A, Viejo-Rodríguez AL, Soler-Simon S, et al. Efficacy and safety of oral and early - switch therapy for community ...
, or MOX 400 mg IV q24h. After a minimum of 3 days IV therapy they could switch to oral therapy (OMC 300 mg q24h or MOX 400 mg q12h); total treatment duration was 7–14 days. Early Clinical Response (ECR; 72 ...
are promising but robust evidence is lacking, most importantly because in many cases clinical efficacy and safety are not properly addressed. Early oral antibiotic switch therapy in neonates could be beneficial ...
, Hulscher ME et al. Barriers to an early switch from intravenous to oral antibiotic therapy in hospitalised patients with CAP . Eur Respir J 2013 ; 41 : 123 – 30 . Google Scholar CrossRef Search ADS PubMed 18 ...
Against Pneumonia [LEAP]-1 and LEAP-2). This pooled analysis evaluated lefamulin efficacy and safety in adults with community -acquired bacterial pneumonia caused by atypical pathogens (Mycoplasma pneumoniae ...
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