In chronic inflammation, cytokines induce the production of nitric oxide (NO . ) that is converted to DNA damaging and carcinogenic peroxynitrite and nitrite. The compounds epigallocatechin gallate (EGCG), carnosol, and curcumin are non-vitamin phytochemicals contained in commonly consumed dietary plants. They are known to be anti-inflammatory and cancer preventive. Therefore, we studied their effect on the generation of peroxynitrite radicals and nitrite. They inhibited lipopolysaccharide (LPS) and interferon-γ (IFNγ) induced nitrite production by mouse peritoneal cells by more than 50% at 2.5–10 μM. Cell viability assays verified that the inhibition was not due to general cellular toxicity.
Cancer Letters – Elsevier
Published: Sep 4, 1995
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