Effects of the acute and chronic restraint stresses on the central histaminergic neuron system of Fischer rat

Effects of the acute and chronic restraint stresses on the central histaminergic neuron system of... The effects of acute and chronic restraint stresses on the brain histamine level and histamine N -methyltransferase activity in Fischer rat brain were studied. The acute restraint stress increased the histamine levels in the diencephalon and nucleus accumbens, and increased the histamine N -methyltransferase activities in the nucleus accumbens and striatum. The chronic restraint stress also increased histamine N -methyltransferase activities in the nucleus accumbens and striatum. These results indicate that the acute and chronic restraint stresses increase the brain histamine turnover, which may partly relate to the vulnerability for stress-induced anxiety and depression. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuroscience Letters Elsevier

Effects of the acute and chronic restraint stresses on the central histaminergic neuron system of Fischer rat

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Publisher
Elsevier
Copyright
Copyright © 1999 Elsevier Science Ireland Ltd
ISSN
0304-3940
DOI
10.1016/S0304-3940(99)00052-X
Publisher site
See Article on Publisher Site

Abstract

The effects of acute and chronic restraint stresses on the brain histamine level and histamine N -methyltransferase activity in Fischer rat brain were studied. The acute restraint stress increased the histamine levels in the diencephalon and nucleus accumbens, and increased the histamine N -methyltransferase activities in the nucleus accumbens and striatum. The chronic restraint stress also increased histamine N -methyltransferase activities in the nucleus accumbens and striatum. These results indicate that the acute and chronic restraint stresses increase the brain histamine turnover, which may partly relate to the vulnerability for stress-induced anxiety and depression.

Journal

Neuroscience LettersElsevier

Published: Mar 5, 1999

References

  • Binding of antidepressants to human brain receptors: focus on newer generation compounds
    Cusack, B.; Nelson, A.; Richelson, E.
  • Histaminergic transmission in the mammalian brain
    Schwartz, J.C.; Arrang, J.M.; Garbarg, M.; Pollard, H.; Rust, M.

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