Effects of kainic acid induced seizures on immediate early gene expression in mice with a targeted mutation of the CREB gene

Effects of kainic acid induced seizures on immediate early gene expression in mice with a... The present study examined the response of immediate early genes following kainic acid induced seizures in mice lacking the alpha and delta isoforms of CREB. mRNA levels for c-fos, c-jun, and Krox-24 were measured following limbic seizure activity and were found to be induced in wild type as well as CREB mutant mice. This effect was also seen for these three mRNAs at the protein level as well as for FOS-B. Furthermore the time course of expression of FOS, JUN, KROX-24, and FOS-B proteins were essentially the same in CREB mutant mice as compared to wild-type controls. These data suggest that CREB alpha and delta are not required for the induction of immediate early genes following pharmacologically induced seizures. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Brain Research Elsevier

Effects of kainic acid induced seizures on immediate early gene expression in mice with a targeted mutation of the CREB gene

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Abstract

The present study examined the response of immediate early genes following kainic acid induced seizures in mice lacking the alpha and delta isoforms of CREB. mRNA levels for c-fos, c-jun, and Krox-24 were measured following limbic seizure activity and were found to be induced in wild type as well as CREB mutant mice. This effect was also seen for these three mRNAs at the protein level as well as for FOS-B. Furthermore the time course of expression of FOS, JUN, KROX-24, and FOS-B proteins were essentially the same in CREB mutant mice as compared to wild-type controls. These data suggest that CREB alpha and delta are not required for the induction of immediate early genes following pharmacologically induced seizures.

Journal

Brain ResearchElsevier

Published: May 29, 1995

References

  • Spatiotemporal induction of immediate early genes in the rat brain after limbic seizures: effects of NMDA-receptor antagonist MK-801
    Gass, P.; Herdegen, T.; Bravo, R.; Kiessling, M.
  • Immediate early gene expression in experimental epilepsy
    Kiessling, M.; Gass, P.
  • Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun
    Morgan, J.I.; Curran

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