Effects of forebrain microinjection of cholecystokinin on dopamine cell firing rate

Effects of forebrain microinjection of cholecystokinin on dopamine cell firing rate In anesthetized rats, midbrain dopamine (DA) neuronal firing rate was differentially sensitive to focal brain microinjection of cholecystokinin peptides (CCK-4 and CCK-8) and N-methyl-D-aspartate (NMDA) into nucleus accumbens, amygdala and prefrontal cortex. Whereas changes in DA neuronal firing rate were frequently observed in response to intra-amygdalar microinjection of CCK peptides, NMDA was most effective in eliciting changes in DA neuronal activity following intra-accumbal microinjection. Thus, stimulation of amygdalar CCK receptors and accumbal excitatory amino acid receptors may participate in the afferent regulation of midbrain DA neuronal function. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Peptides Elsevier

Effects of forebrain microinjection of cholecystokinin on dopamine cell firing rate

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Publisher
Elsevier
Copyright
Copyright © 2001 Elsevier Science Inc.
ISSN
0196-9781
DOI
10.1016/S0196-9781(01)00427-2
Publisher site
See Article on Publisher Site

Abstract

In anesthetized rats, midbrain dopamine (DA) neuronal firing rate was differentially sensitive to focal brain microinjection of cholecystokinin peptides (CCK-4 and CCK-8) and N-methyl-D-aspartate (NMDA) into nucleus accumbens, amygdala and prefrontal cortex. Whereas changes in DA neuronal firing rate were frequently observed in response to intra-amygdalar microinjection of CCK peptides, NMDA was most effective in eliciting changes in DA neuronal activity following intra-accumbal microinjection. Thus, stimulation of amygdalar CCK receptors and accumbal excitatory amino acid receptors may participate in the afferent regulation of midbrain DA neuronal function.

Journal

PeptidesElsevier

Published: Jul 1, 2001

References

  • Effects of flumazenil on cholecystokinin tetrapeptide-induced panic symptoms in healthy volunteers
    Bradwejn, J.; Koszycki, D.; Dutertre, A.C.; Paradis, M.; Bourin, M.
  • Effects of administration of cholecystokinin into the VTA on DA overflow in nucleus accumbens and amygdala of freely moving rats
    Hamilton, M.E.; Freeman, A.S.
  • Overflow of dopamine and cholecystokinin in rat nucleus accumbens in response to acute drug administration
    Hamilton, M.E.; Redondo, J.-L.; Freeman, A.S.
  • Cholecystokinergic innervation of nucleus accumbens subregions
    Lanca, A.J.; De Cabo, C.; Arifuzzaman, A.I.; Vaccarino, F.J.
  • Inhibition of A9 and A10 dopamine cells by the cholecystokinin-B antagonist LY262691
    Rasmussen, K.; Howbert, J.J.; Stockton, M.E.
  • Effects of electrical stimulation of the central nucleus of the amygdala on the in vivo electrophysiological activity of rat nigral dopaminergic neurons
    Rouillard, C.; Freeman, A.S.
  • CCK-8 injected into the nucleus accumbens attenuates the supersensitive locomotor response to apomorphine in 6-OHDA and chronic-neuroleptic treated rats
    Weiss, F.; Ettenberg, A.; Koob, G.F.
  • Synaptic regulation of mesocorticolimbic dopamine neurons
    White, F.J.

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