Effects of dopamine receptor antagonists on ongoing maternal behavior in rats

Effects of dopamine receptor antagonists on ongoing maternal behavior in rats The effects of different peripheral doses of four dopamine (DA) receptor antagonists on general activity and maternal behavior were examined in lactating female rats. Administration of the classic D1-like and D2-like DA receptor blocker haloperidol (0.1 and 0.05 mg/kg) disrupted pup retrieval and nest-building behaviors and reduced motor activity. Pimozide (0.5 and 0.2 mg/kg), which has more affinity for DA D2-like receptors, mildly disrupted pup retrieval while showing no significant influence on open-field behaviors. The putative DA D 4 receptor blocker, clozapine (1.5 and 1.0 mg/kg) reduced motor activity significantly, while only 1.0 mg/kg dose significantly decreased percent of rats displaying nest building. The DA D1-like receptor blocker SKF-83566 (0.2 and 0.1 mg/kg) significantly reduced pup retrieval, nest building and motor activity. These results suggest a role for DA receptors in ongoing maternal behavior that correlates directly with general activity. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmacology Biochemistry and Behavior Elsevier

Effects of dopamine receptor antagonists on ongoing maternal behavior in rats

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Publisher
Elsevier
Copyright
Copyright © 2001 Elsevier Science Inc.
ISSN
0091-3057
eISSN
1873-5177
D.O.I.
10.1016/S0091-3057(01)00471-3
Publisher site
See Article on Publisher Site

Abstract

The effects of different peripheral doses of four dopamine (DA) receptor antagonists on general activity and maternal behavior were examined in lactating female rats. Administration of the classic D1-like and D2-like DA receptor blocker haloperidol (0.1 and 0.05 mg/kg) disrupted pup retrieval and nest-building behaviors and reduced motor activity. Pimozide (0.5 and 0.2 mg/kg), which has more affinity for DA D2-like receptors, mildly disrupted pup retrieval while showing no significant influence on open-field behaviors. The putative DA D 4 receptor blocker, clozapine (1.5 and 1.0 mg/kg) reduced motor activity significantly, while only 1.0 mg/kg dose significantly decreased percent of rats displaying nest building. The DA D1-like receptor blocker SKF-83566 (0.2 and 0.1 mg/kg) significantly reduced pup retrieval, nest building and motor activity. These results suggest a role for DA receptors in ongoing maternal behavior that correlates directly with general activity.

Journal

Pharmacology Biochemistry and BehaviorElsevier

Published: Mar 1, 2001

References

  • Effects of clozapine on cerebral catecholaminergic neuron systems
    Bartholini, G; Haefely, W; Jalfre, M; Keller, HH; Pletscher, A
  • Effects of single and long-term haloperidol administration on open-field behavior of rats
    Bernardi, MM; Palermo-Neto, J
  • Changes in progressive ratio responding for intravenous cocaine throughout the reproductive process in female rats
    Hecht, GS; Spear, NE; Spear, LP
  • Maternal motivation of lactating rats is disrupted by low dosages of haloperidol
    Keer, SE; Stern, JM
  • Investigation into the role of cholecystokinin (CCK) in the induction and maintenance of maternal behavior in rats
    Mann, PE; Felicio, LF; Bridges, RS
  • Differential role of cholecystokinin receptor subtypes in opioid modulation of ongoing maternal behavior
    Miranda-Paiva, CM; Felicio, LF
  • Haloperidol inhibits maternal retrieval and licking, but enhances nursing behavior and litter weight gains in lactating rats
    Stern, JM; Taylor, LA
  • Modulation of apomorphine-induced stereotyped behavior by cholecystokinin
    Tieppo, CA; Nasello, AG; Felicio, LF

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