Effects of diet and/or exercise on the adipocytokine and inflammatory cytokine levels of postmenopausal women with type 2 diabetes

Effects of diet and/or exercise on the adipocytokine and inflammatory cytokine levels of... This study examined the independent and combined effects of diet and exercise on adipocytokine and inflammatory cytokines in postmenopausal women with type 2 diabetes. Using a randomized, controlled design, 33 women (age, 50-70 years) were assigned to diet alone (D), exercise alone (EX), or diet + exercise (D + E) for 14 weeks. Before and after the interventions, blood samples for adipocytokines and inflammatory markers were drawn, a meal test was performed, and abdominal fat distribution was measured by magnetic resonance imaging (MRI). Body weight decreased ∼4.5 ± 0.6 kg ( P < .05) after the D and D + E interventions, whereas only small changes in body weight were found with the exercise-alone intervention. Plasma C-reactive protein levels were decreased by ∼15% with all 3 interventions, whereas leptin levels were reduced with the D and D + E intervention (D: pre = 48.7 ± 6.0, post = 38.9 ± 5.0 ng/mL; D + E: pre = 38.5 ± 6.0, post = 22.9 ± 5.0 ng/mL; P < .05) with no differences between groups. There was a trend for leptin levels to decrease in the EX group ( P = .06). Plasma resistin levels were not altered by the 3 interventions from pre- to posttreatment (D: pre = 6.9 ± 0.6, post = 6.2 ± 0.4 ng/mL; D + E: pre = 5.6 ± 0.6, post = 5.7 ± 0.4 ng/mL; E: pre = 6.2 ± 0.6, post = 5.9 ± 0.6 ng/mL, P > .05), and no differences in adiponectin and tumor necrosis factor α (TNF- α ) levels were found. Visceral adipose tissue and tumor necrosis factor α were the only predictors of calculated insulin resistance ( P < .05), explaining 43% of the variability. A typically prescribed weight loss program with lifestyle changes resulted in few changes in adipocytokines and inflammatory cytokines in older women with type 2 diabetes, suggesting that dramatic weight loss or clinical interventions are needed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Metabolism Elsevier

Effects of diet and/or exercise on the adipocytokine and inflammatory cytokine levels of postmenopausal women with type 2 diabetes

Loading next page...
 
/lp/elsevier/effects-of-diet-and-or-exercise-on-the-adipocytokine-and-inflammatory-Qr1j9UT9Oh
Publisher
Elsevier
Copyright
Copyright © 2005 Elsevier Inc.
ISSN
0026-0495
D.O.I.
10.1016/j.metabol.2005.01.033
Publisher site
See Article on Publisher Site

Abstract

This study examined the independent and combined effects of diet and exercise on adipocytokine and inflammatory cytokines in postmenopausal women with type 2 diabetes. Using a randomized, controlled design, 33 women (age, 50-70 years) were assigned to diet alone (D), exercise alone (EX), or diet + exercise (D + E) for 14 weeks. Before and after the interventions, blood samples for adipocytokines and inflammatory markers were drawn, a meal test was performed, and abdominal fat distribution was measured by magnetic resonance imaging (MRI). Body weight decreased ∼4.5 ± 0.6 kg ( P < .05) after the D and D + E interventions, whereas only small changes in body weight were found with the exercise-alone intervention. Plasma C-reactive protein levels were decreased by ∼15% with all 3 interventions, whereas leptin levels were reduced with the D and D + E intervention (D: pre = 48.7 ± 6.0, post = 38.9 ± 5.0 ng/mL; D + E: pre = 38.5 ± 6.0, post = 22.9 ± 5.0 ng/mL; P < .05) with no differences between groups. There was a trend for leptin levels to decrease in the EX group ( P = .06). Plasma resistin levels were not altered by the 3 interventions from pre- to posttreatment (D: pre = 6.9 ± 0.6, post = 6.2 ± 0.4 ng/mL; D + E: pre = 5.6 ± 0.6, post = 5.7 ± 0.4 ng/mL; E: pre = 6.2 ± 0.6, post = 5.9 ± 0.6 ng/mL, P > .05), and no differences in adiponectin and tumor necrosis factor α (TNF- α ) levels were found. Visceral adipose tissue and tumor necrosis factor α were the only predictors of calculated insulin resistance ( P < .05), explaining 43% of the variability. A typically prescribed weight loss program with lifestyle changes resulted in few changes in adipocytokines and inflammatory cytokines in older women with type 2 diabetes, suggesting that dramatic weight loss or clinical interventions are needed.

Journal

MetabolismElsevier

Published: Jul 1, 2005

References

  • Enzyme-linked immunosorbent assay for circulating human resistin: resistin concentration in normal subjects and patients with type 2 diabetes
    Fujinami, A.; Obayashi, H.; Ohta, K.; Ichimura, T.; Nishimura, M.; Matsui, H.
  • Lowering of circulating insulin and leptin is closely associated following weight reduction after vertical banded gastroplasty in obese women
    Guldstrand, M.; Backman, L.; Adamson, U.
  • Concurrent reductions of serum leptin and lipids during weight loss in obese men with type II diabetes
    Halle, M.; Berg, A.; Garwers, U.; Grathwohl, D.; Knisel, W.; Keul, J.
  • Plasma adiponectin concentrations do not increase in association with moderate weight loss in insulin-resistant, obese women
    Abbasi, F.; Lamendola, C.; McLaughlin, T.; Hayden, J.; Reaven, G.M.; Rea, P.D.
  • Racial differences in subcutaneous and visceral fat distribution in postmenopausal black and white women
    Kanaley, J.A.; Giannopoulou, I.; Tillapaugh-Fay, G.; Nappi, J.S.; Ploutz-Snyder, L.L.
  • Effect of short-term exercise training on leptin and insulin action
    Houmard, J.A.; Cox, J.H.; Maclean, P.S.; Barakat, H.A.
  • Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans
    Bruun, J.M.; Lihn, A.S.; Verdich, C.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off