Effects of conditioned fear stress on serotonin neurotransmission and freezing behavior in rats

Effects of conditioned fear stress on serotonin neurotransmission and freezing behavior in rats In an attempt to clarify the role of the brain serotonergic system in the psychopathology of anxiety, we examined the effect of a psychological stress, conditioned fear stress, on extracellular serotonin (5-hydroxytryptamine, 5-HT) concentrations in the rat medial prefrontal cortex using the method of in vivo microdialysis, while simultaneously observing conditioned fear stress-induced freezing behavior, an index of anxiety. Conditioned fear stress increased extracellular 5-HT levels in the medial prefrontal cortex, and this 5-HT level increase was followed by a resolution of the freezing behavior. A dose of 10 mg/kg of a selective 5-HT reuptake inhibitor, citalopram, administered 60 min before exposure to conditioned fear stress increased extracellular 5-HT concentrations immediately and potently, reducing freezing behavior. These findings strongly suggest that facilitation of brain 5-HT neurotransmission decreases anxiety, which is in agreement with the clinical reports that selective 5-HT reuptake inhibitors are effective in the treatment of anxiety disorders. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Pharmacology Elsevier

Effects of conditioned fear stress on serotonin neurotransmission and freezing behavior in rats

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Publisher
Elsevier
Copyright
Copyright © 1999 Elsevier Science B.V.
ISSN
0014-2999
DOI
10.1016/S0014-2999(99)00441-0
Publisher site
See Article on Publisher Site

Abstract

In an attempt to clarify the role of the brain serotonergic system in the psychopathology of anxiety, we examined the effect of a psychological stress, conditioned fear stress, on extracellular serotonin (5-hydroxytryptamine, 5-HT) concentrations in the rat medial prefrontal cortex using the method of in vivo microdialysis, while simultaneously observing conditioned fear stress-induced freezing behavior, an index of anxiety. Conditioned fear stress increased extracellular 5-HT levels in the medial prefrontal cortex, and this 5-HT level increase was followed by a resolution of the freezing behavior. A dose of 10 mg/kg of a selective 5-HT reuptake inhibitor, citalopram, administered 60 min before exposure to conditioned fear stress increased extracellular 5-HT concentrations immediately and potently, reducing freezing behavior. These findings strongly suggest that facilitation of brain 5-HT neurotransmission decreases anxiety, which is in agreement with the clinical reports that selective 5-HT reuptake inhibitors are effective in the treatment of anxiety disorders.

Journal

European Journal of PharmacologyElsevier

Published: Jul 28, 1999

References

  • 5HT drugs in animal models of anxiety
    Handley, S.L.; Mc Blane, J.W.
  • Serotonin reuptake inhibitors reduce conditioned fear stress-induced freezing behavior in rats
    Hashimoto, S.; Inoue, T.; Koyama, T.
  • Effects of the co-administration of 5-HT 1A receptor antagonists with an SSRI in conditioned fear stress-induced freezing behavior
    Hashimoto, S.; Inoue, T.; Koyama, T.
  • Serotonergic activation reduced defensive freezing in the conditioned fear paradigm
    Inoue, T.; Tsuchiya, K.; Koyama, T.
  • In vivo measurement of extracellular 5-hydroxytryptamine in hippocampus of the anaesthetized rat using microdialysis: change in relation to 5-hydroxytryptaminergic neuronal activity
    Sharp, T.; Bramwell, S.R.; Clark, D.; Grahame-Smith, D.G.
  • Psychopharmacological treatment of social phobia: a double blind placebo controlled study with fluvoxamine
    Van Vliet, I.M.; Den Boer, J.A.; Westenberg, H.G.

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