Effects of chronic opiate and opioid antagonist treatment on striatal opioid peptides

Effects of chronic opiate and opioid antagonist treatment on striatal opioid peptides It has long been speculated that feedback inhibition of endogenous opioid neurons may have a role in opiate tolerance and dependence. However, in studies in which opiates or opioid antagonists have been administered to animals, mixed results have been obtained on the ability of these drugs to regulate endogenous opioids. The present studies were undertaken to determine the effects of chronic administration of opiate drugs on opioid peptides. These studies focused on the regulation of prodynorphin (Prodyn) and proenkephalin (Proenk) peptides in striatal tissue. Morphine, whether administered by chronic infusion or repeated injection, was found to increase the concentration of Prodyn peptides in striatum. Increases were statistically significant in the sensorimotor dorsal striatum (caudate-putamen) but not in the limbic-motor ventral striatum (nucleus accumbens-olfactory tubercle). No changes in Prodyn peptides were found following chronic administration of the opioid antagonist naltrexone. No changes in the Proenk peptide MERGL were found following chronic treatment with morphine or naltrexone. These studies are consistent with the suggestion that Prodyn neurons may have a role in the consequences of long-term opiate administration. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Brain Research Elsevier

Effects of chronic opiate and opioid antagonist treatment on striatal opioid peptides

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Publisher
Elsevier
Copyright
Copyright © 1995 Elsevier Science B.V. All rights reserved
ISSN
0006-8993
DOI
10.1016/0006-8993(95)00809-5
Publisher site
See Article on Publisher Site

Abstract

It has long been speculated that feedback inhibition of endogenous opioid neurons may have a role in opiate tolerance and dependence. However, in studies in which opiates or opioid antagonists have been administered to animals, mixed results have been obtained on the ability of these drugs to regulate endogenous opioids. The present studies were undertaken to determine the effects of chronic administration of opiate drugs on opioid peptides. These studies focused on the regulation of prodynorphin (Prodyn) and proenkephalin (Proenk) peptides in striatal tissue. Morphine, whether administered by chronic infusion or repeated injection, was found to increase the concentration of Prodyn peptides in striatum. Increases were statistically significant in the sensorimotor dorsal striatum (caudate-putamen) but not in the limbic-motor ventral striatum (nucleus accumbens-olfactory tubercle). No changes in Prodyn peptides were found following chronic administration of the opioid antagonist naltrexone. No changes in the Proenk peptide MERGL were found following chronic treatment with morphine or naltrexone. These studies are consistent with the suggestion that Prodyn neurons may have a role in the consequences of long-term opiate administration.

Journal

Brain ResearchElsevier

Published: Nov 6, 1995

References

  • The neostriatal mosaic: multiple levels of compartmental organization in the basal ganglia
    Gerfen, C.R.
  • Molecular alterations in the neostriatum of human cocaine addicts
    Hurd, Y.L.; Herkenham, M.
  • Nucleus accumbens as a substrate for the aversive stimulus effects of opiate withdrawal
    Koob, G.F.; Wall, T.L.; Bloom, F.E.
  • Multiple mechanisms of withdrawal from opioid drugs
    Redmond, D.E.J.; Krystal, J.H.
  • A review of the role of anti-opioid peptides in morphine tolerance and dependence
    Rothman, R.B.
  • Evidence for a selective processing of proenkephalin B into different opioid peptide forms in particular regions of rat brain and pituitary
    Seizinger, B.R.; Grimm, C.; Höllt, V.; Herz, A.

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