Effects of bisphenol A on adipokine release from human adipose tissue: Implications for the metabolic syndrome

Effects of bisphenol A on adipokine release from human adipose tissue: Implications for the... Bisphenol A (BPA) is one of the most prevalent and best studied endocrine disruptors. After years of exposure to consumer products containing BPA, most individuals tested have circulating BPA at the low nanomolar levels. In addition to its well documented actions on the reproductive system, BPA exerts a wide variety of metabolic effects. This review summarizes recent findings on the ability of BPA, at environmentally relevant doses, to inhibit adiponectin and stimulate the release of inflammatory adipokines such as interleukin-6 (IL-6) and tumor necrosis factor α (TNFα) from human adipose tissue. Expression of several classical and non-classical estrogen receptors in human adipose tissue raises the possibility of their involvement as mediators of BPA actions. The implications of these observations to the obesity-related metabolic syndrome and its sequelae are discussed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular and Cellular Endocrinology Elsevier

Effects of bisphenol A on adipokine release from human adipose tissue: Implications for the metabolic syndrome

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Publisher
Elsevier
Copyright
Copyright © 2009 Elsevier Ireland Ltd
ISSN
0303-7207
DOI
10.1016/j.mce.2009.02.022
Publisher site
See Article on Publisher Site

Abstract

Bisphenol A (BPA) is one of the most prevalent and best studied endocrine disruptors. After years of exposure to consumer products containing BPA, most individuals tested have circulating BPA at the low nanomolar levels. In addition to its well documented actions on the reproductive system, BPA exerts a wide variety of metabolic effects. This review summarizes recent findings on the ability of BPA, at environmentally relevant doses, to inhibit adiponectin and stimulate the release of inflammatory adipokines such as interleukin-6 (IL-6) and tumor necrosis factor α (TNFα) from human adipose tissue. Expression of several classical and non-classical estrogen receptors in human adipose tissue raises the possibility of their involvement as mediators of BPA actions. The implications of these observations to the obesity-related metabolic syndrome and its sequelae are discussed.

Journal

Molecular and Cellular EndocrinologyElsevier

Published: May 25, 2009

References

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  • Bisphenol A affects glucose transport in mouse 3T3-F442A adipocytes
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