Effects of BDNF receptor antagonist on the severity of physical and psychological dependence, morphine-induced locomotor sensitization and the ventral tegmental area-nucleus accumbens BDNF levels in morphine- dependent and withdrawn rats

Effects of BDNF receptor antagonist on the severity of physical and psychological dependence,... •ANA-12 exacerbated morphine withdrawal signs in morphine-dependent rats.•ANA-12 partially ameliorated increased anxiety-like behavior in morphine-dependent rats.•ANA-12 did not affect morphine-induced hyperlocomotion after morphine withdrawal.•ANA-12 did not alter the VTA-NAc BDNF levels in morphine-dependent and withdrawn rats. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuroscience Letters Elsevier

Effects of BDNF receptor antagonist on the severity of physical and psychological dependence, morphine-induced locomotor sensitization and the ventral tegmental area-nucleus accumbens BDNF levels in morphine- dependent and withdrawn rats

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier B.V.
ISSN
0304-3940
D.O.I.
10.1016/j.neulet.2017.12.061
Publisher site
See Article on Publisher Site

Abstract

•ANA-12 exacerbated morphine withdrawal signs in morphine-dependent rats.•ANA-12 partially ameliorated increased anxiety-like behavior in morphine-dependent rats.•ANA-12 did not affect morphine-induced hyperlocomotion after morphine withdrawal.•ANA-12 did not alter the VTA-NAc BDNF levels in morphine-dependent and withdrawn rats.

Journal

Neuroscience LettersElsevier

Published: Mar 6, 2018

References

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