Effects of aerobic exercise on C-reactive protein, body composition, and maximum oxygen consumption in adults: a meta-analysis of randomized controlled trials

Effects of aerobic exercise on C-reactive protein, body composition, and maximum oxygen... The aim of the study was to use the meta-analytic approach to examine the effects of aerobic exercise on C-reactive protein (CRP) in adults. Secondary outcomes included changes in body weight in kilograms, percentage of body fat, and maximum oxygen consumption (V̇ o 2 max) in mL kg −1 min −1 . Studies were retrieved using computerized literature searches, cross-referencing, and hand searching. Inclusion criteria were assessment of CRP in randomized controlled trials published in the English language between January 1, 1990, and January 1, 2006. Studies were also limited to aerobic exercise interventions lasting 4 weeks or more in adults 18 years or older. Five studies representing 323 male and female subjects (171 exercise, 152 control) and 6 outcomes for CRP were available for pooling. A nonsignificant reduction of approximately 3% was observed for CRP in the exercise groups (mean ± SEM, −0.11 ± 0.14 mg/L; 95% confidence interval (CI), −0.39 to 0.17 mg/L) using a random-effects model. Statistically significant reductions of approximately 4% were found for body weight (mean ± SEM, −3.4 ± 1.0 kg; 95% CI, −5.3 to −1.5 kg) and percentage of body fat (mean ± SEM, −1.4% ± 0.4%; 95% CI, −2.3% to −0.6%), whereas a statistically significant increase of 12% was found for V̇ o 2 max (mean ± SEM, 3.3 ± 0.9 mL kg −1 min −1 ; 95% CI, 1.5 to 5.1 mL kg −1 min −1 ). The results of our study suggest that aerobic exercise does not reduce CRP levels in adults, but does improve measures of body composition and physical fitness. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Metabolism Elsevier

Effects of aerobic exercise on C-reactive protein, body composition, and maximum oxygen consumption in adults: a meta-analysis of randomized controlled trials

Metabolism, Volume 55 (11) – Nov 1, 2006

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Publisher
Elsevier
Copyright
Copyright © 2006 Elsevier Inc.
ISSN
0026-0495
D.O.I.
10.1016/j.metabol.2006.06.021
Publisher site
See Article on Publisher Site

Abstract

The aim of the study was to use the meta-analytic approach to examine the effects of aerobic exercise on C-reactive protein (CRP) in adults. Secondary outcomes included changes in body weight in kilograms, percentage of body fat, and maximum oxygen consumption (V̇ o 2 max) in mL kg −1 min −1 . Studies were retrieved using computerized literature searches, cross-referencing, and hand searching. Inclusion criteria were assessment of CRP in randomized controlled trials published in the English language between January 1, 1990, and January 1, 2006. Studies were also limited to aerobic exercise interventions lasting 4 weeks or more in adults 18 years or older. Five studies representing 323 male and female subjects (171 exercise, 152 control) and 6 outcomes for CRP were available for pooling. A nonsignificant reduction of approximately 3% was observed for CRP in the exercise groups (mean ± SEM, −0.11 ± 0.14 mg/L; 95% confidence interval (CI), −0.39 to 0.17 mg/L) using a random-effects model. Statistically significant reductions of approximately 4% were found for body weight (mean ± SEM, −3.4 ± 1.0 kg; 95% CI, −5.3 to −1.5 kg) and percentage of body fat (mean ± SEM, −1.4% ± 0.4%; 95% CI, −2.3% to −0.6%), whereas a statistically significant increase of 12% was found for V̇ o 2 max (mean ± SEM, 3.3 ± 0.9 mL kg −1 min −1 ; 95% CI, 1.5 to 5.1 mL kg −1 min −1 ). The results of our study suggest that aerobic exercise does not reduce CRP levels in adults, but does improve measures of body composition and physical fitness.

Journal

MetabolismElsevier

Published: Nov 1, 2006

References

  • Atherosclerosis is an inflammatory disease
    Ross, R.
  • Meta-analysis of randomized controlled trials
    Sacks, H.S.; Berrier, J.; Reitman, D.
  • Effect of 8 wk of bicycle training on the immune system of patients with rheumatoid arthritis
    Baslund, B.; Lyngberg, K.; Andersen, V.
  • Effect of six months' exercise training on C-reactive protein levels in healthy elderly subjects
    Hammett, C.J.; Oxenham, H.C.; Baldi, J.C.
  • Exercise training is not associated with improved levels of C-reactive protein or adiponectin
    Marcell, T.J.; McAuley, K.A.; Traustadottir, T.
  • Reduction in C-reactive protein through cardiac rehabilitation and exercise training
    Milani, R.V.; Lavie, C.J.; Mehra, M.R.
  • Effect of exercise training on plasma levels of C-reactive protein in healthy adults: the HERITAGE Family Study
    Lakka, T.A.; Lakka, H.-M.; Rankinen, T.
  • Practical methodology of meta-analyses (overviews) using updated individual patient data
    Stewart, L.A.; Clarke, M.J.

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