Effect of weight loss on some serum cytokines in human obesity: increase in IL-10 after weight loss

Effect of weight loss on some serum cytokines in human obesity: increase in IL-10 after weight loss Obesity is a major risk factor for hypertension, coronary artery disease and type 2 diabetes. Weight loss is associated with significant metabolic benefits. Our objective was to examine changes in adipocytokines and interleukin (IL) 10 in obese subjects before and after weight loss. We measured anthropometric parameters, adipocytokine and IL-10 in 78 obese people who had visited obesity clinics at five university hospitals (Ajou, Ulsan, Catholic, Hanyang and Yonsei) in Korea. They restricted their caloric intake to less than their usual intake (by 500kcal), were administered sibutramine and were given a program of exercise for 12 weeks. After 12 weeks, weight, body mass index, waist circumference, hip circumference, waist-to-hip ratio, total body fat, total cholesterol, triglyceride, tumor necrosis factor α (TNF-α), IL-6, resistin and leptin had significantly decreased, while adiponectin and IL-10 had significantly increased. A bivariate correlation analysis found that increment in IL-10 and baseline IL-10 levels significantly correlated with decrement in TNF-α ( P <.01) and baseline adiponectin ( r =.52, P <.001), respectively. These results were confirmed in a multiple regression analysis. The results suggest that weight loss after caloric restriction and medical treatment in obesity can improve metabolic risk factors through changes in some cytokines. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Nutritional Biochemistry Elsevier

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Publisher
Elsevier
Copyright
Copyright © 2008 Elsevier Inc.
ISSN
0955-2863
D.O.I.
10.1016/j.jnutbio.2007.05.007
Publisher site
See Article on Publisher Site

Abstract

Obesity is a major risk factor for hypertension, coronary artery disease and type 2 diabetes. Weight loss is associated with significant metabolic benefits. Our objective was to examine changes in adipocytokines and interleukin (IL) 10 in obese subjects before and after weight loss. We measured anthropometric parameters, adipocytokine and IL-10 in 78 obese people who had visited obesity clinics at five university hospitals (Ajou, Ulsan, Catholic, Hanyang and Yonsei) in Korea. They restricted their caloric intake to less than their usual intake (by 500kcal), were administered sibutramine and were given a program of exercise for 12 weeks. After 12 weeks, weight, body mass index, waist circumference, hip circumference, waist-to-hip ratio, total body fat, total cholesterol, triglyceride, tumor necrosis factor α (TNF-α), IL-6, resistin and leptin had significantly decreased, while adiponectin and IL-10 had significantly increased. A bivariate correlation analysis found that increment in IL-10 and baseline IL-10 levels significantly correlated with decrement in TNF-α ( P <.01) and baseline adiponectin ( r =.52, P <.001), respectively. These results were confirmed in a multiple regression analysis. The results suggest that weight loss after caloric restriction and medical treatment in obesity can improve metabolic risk factors through changes in some cytokines.

Journal

The Journal of Nutritional BiochemistryElsevier

Published: Jun 1, 2008

References

  • Endogenous interleukin 10 prevents apoptosis in macrophages during Salmonella infection
    Arai, T.; Hiromatsu, K.; Nishimura, H.
  • Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes
    Wolf, A.M.; Wolf, D.; Rumpold, H.; Enrich, B.; Tilg, H.
  • Sibutramine improves insulin sensitivity without alteration of serum adiponectin in obese subjects with type 2 diabetes
    Hung, Y.J.; Chen, Y.C.; Pei, D.

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