Effect of weight loss in morbidly obese infertile women on IVF outcome

Effect of weight loss in morbidly obese infertile women on IVF outcome <h5>Objective</h5> It has been reported that morbidly obese women (MOW) had significantly lower pregnancy rates compared to the obese ones following IVF treatments. The effect of weight loss on the IVF outcome is not well-studied. The purpose of this study is to analyze the effect of weight loss on IVF treatments.</P><h5>Design</h5> Retrospective cohort.</P><h5>Materials and Methods</h5> MOW with primary infertility and prior unsuccessful IVF treatment cycles were included. They were advised to lose weight in a year time and restart IVF treatment. Women who managed to reduce their BMI to <35kg/m 2 was considered as the study group (A), and women who did not reduce their BMI to <35kg/m 2 was considered as the control group (B). Cycles' characteristics of pre- and post-weight loss were compared for group A patients.</P><h5>Results</h5> Out of 90 women, 25 were able to lose weight to become obese from morbid obesity and had 49 IVF cycles. The other 65 women did not lose weight and decided to continue IVF without losing weight and had 108 IVF cycles. The women in group A were significantly younger (31.4 vs 34.7) and had lower BMI (33.1 vs. 37.9) compared to group B. Group A required less HMG for stimulation (37.3 vs. 44.2 ampoules) had higher number of oocytes, zygotes and embryos. Group A had significantly less cancellation rate (6.1% vs 21.3). There was a trend toward better clinical pregnancy rate per started cycle in group A (22.5% vs 18.5%). Pre- and post- weight loss parameters were compared within the group A, there was no significant difference in the numbers of HMG ampoules, oocytes, zygotes and embryos. However, there were significantly fewer cancellations and more embryos available for transfer after the weight loss.</P><h5>Conclusion</h5> Among MOW, the overall compliance with weight loss was low and younger ones were more prone to lose weight. Changing from morbidly obese to the obese status had minimum impact on IVF outcome. Therefore, when counseling MOW, the balance between the times spent and the minimum gain from a 10% weight loss should be carefully considered.</P> http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Fertility and Sterility Elsevier

Effect of weight loss in morbidly obese infertile women on IVF outcome

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Publisher
Elsevier
Copyright
Copyright © 2012 Elsevier Ltd
ISSN
0015-0282
D.O.I.
10.1016/j.fertnstert.2012.07.745
Publisher site
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Abstract

<h5>Objective</h5> It has been reported that morbidly obese women (MOW) had significantly lower pregnancy rates compared to the obese ones following IVF treatments. The effect of weight loss on the IVF outcome is not well-studied. The purpose of this study is to analyze the effect of weight loss on IVF treatments.</P><h5>Design</h5> Retrospective cohort.</P><h5>Materials and Methods</h5> MOW with primary infertility and prior unsuccessful IVF treatment cycles were included. They were advised to lose weight in a year time and restart IVF treatment. Women who managed to reduce their BMI to <35kg/m 2 was considered as the study group (A), and women who did not reduce their BMI to <35kg/m 2 was considered as the control group (B). Cycles' characteristics of pre- and post-weight loss were compared for group A patients.</P><h5>Results</h5> Out of 90 women, 25 were able to lose weight to become obese from morbid obesity and had 49 IVF cycles. The other 65 women did not lose weight and decided to continue IVF without losing weight and had 108 IVF cycles. The women in group A were significantly younger (31.4 vs 34.7) and had lower BMI (33.1 vs. 37.9) compared to group B. Group A required less HMG for stimulation (37.3 vs. 44.2 ampoules) had higher number of oocytes, zygotes and embryos. Group A had significantly less cancellation rate (6.1% vs 21.3). There was a trend toward better clinical pregnancy rate per started cycle in group A (22.5% vs 18.5%). Pre- and post- weight loss parameters were compared within the group A, there was no significant difference in the numbers of HMG ampoules, oocytes, zygotes and embryos. However, there were significantly fewer cancellations and more embryos available for transfer after the weight loss.</P><h5>Conclusion</h5> Among MOW, the overall compliance with weight loss was low and younger ones were more prone to lose weight. Changing from morbidly obese to the obese status had minimum impact on IVF outcome. Therefore, when counseling MOW, the balance between the times spent and the minimum gain from a 10% weight loss should be carefully considered.</P>

Journal

Fertility and SterilityElsevier

Published: Sep 1, 2012

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