Effect of sparteine on status epilepticus induced in rats by pentylenetetrazole, pilocarpine and kainic acid

Effect of sparteine on status epilepticus induced in rats by pentylenetetrazole, pilocarpine and... The long-term effects of status epilepticus (SE) include severe clinical conditions that result in disorders of various organs and systems as well as neurological damage that could lead to death. Sparteine is a quinolizidine alkaloid synthesized from most Lupine species, and its anticonvulsive effect was evaluated in the pentylenetetrazole model of SE. However, efforts to clearly determine the anticonvulsive effect of sparteine have not been made previously. For this reason, we consider it important to study the anticonvulsant effects of sparteine at the level of behavior and EEG activity in three different SE models. The animals of the control groups, which received intraperitoneal pentylenetetrazole (90mg/kg), kainic acid (9mg/kg) or pilocarpine (370mg/kg), exhibited convulsive behavior and epileptiform activity. After sparteine pretreatment (13mg/kg, administered 30min before the convulsive drug), the animals administered pentylenetetrazole and pilocarpine exhibited reduced mortality rates compared with the corresponding control groups, while the animals administered kainic acid exhibited a delayed onset of convulsive behavior and decreased seizure duration compared with the corresponding control group. In the three models of SE, a significant reduction in the amplitude and frequency of discharge trains was observed. These results support the anticonvulsant effect of low doses of sparteine and allow us to direct our efforts to other new anticonvulsant strategies for seizure treatment. However, it is necessary to perform more experiments to determine the precise mechanism through which sparteine produces an anticonvulsant effect at this concentration. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Brain Research Elsevier

Effect of sparteine on status epilepticus induced in rats by pentylenetetrazole, pilocarpine and kainic acid

Loading next page...
 
/lp/elsevier/effect-of-sparteine-on-status-epilepticus-induced-in-rats-by-e0QpEBUnUc
Publisher
Elsevier
Copyright
Copyright © 2015 Elsevier B.V.
ISSN
0006-8993
D.O.I.
10.1016/j.brainres.2015.07.017
Publisher site
See Article on Publisher Site

Abstract

The long-term effects of status epilepticus (SE) include severe clinical conditions that result in disorders of various organs and systems as well as neurological damage that could lead to death. Sparteine is a quinolizidine alkaloid synthesized from most Lupine species, and its anticonvulsive effect was evaluated in the pentylenetetrazole model of SE. However, efforts to clearly determine the anticonvulsive effect of sparteine have not been made previously. For this reason, we consider it important to study the anticonvulsant effects of sparteine at the level of behavior and EEG activity in three different SE models. The animals of the control groups, which received intraperitoneal pentylenetetrazole (90mg/kg), kainic acid (9mg/kg) or pilocarpine (370mg/kg), exhibited convulsive behavior and epileptiform activity. After sparteine pretreatment (13mg/kg, administered 30min before the convulsive drug), the animals administered pentylenetetrazole and pilocarpine exhibited reduced mortality rates compared with the corresponding control groups, while the animals administered kainic acid exhibited a delayed onset of convulsive behavior and decreased seizure duration compared with the corresponding control group. In the three models of SE, a significant reduction in the amplitude and frequency of discharge trains was observed. These results support the anticonvulsant effect of low doses of sparteine and allow us to direct our efforts to other new anticonvulsant strategies for seizure treatment. However, it is necessary to perform more experiments to determine the precise mechanism through which sparteine produces an anticonvulsant effect at this concentration.

Journal

Brain ResearchElsevier

Published: Oct 22, 2015

References

  • Differential phospholipase C-dependent modulation of TASK and TREK two-pore domain K+ channels in rat thalamocortical relay neurons
    Bista, P.; Pawlowski, M.; Cerina, M.; Ehling, P.; Leist, M.; Meuth, P.; Aissaoui, A.; Borsotto, M.
  • Nicotinic agonist, antagonist, and modulation from natural sources
    Daly, J.W.
  • Effect of carbamazepine and valproate monotherapy on cardiovascular risks in epileptic children
    Harit, D.; Aggarwal, A.; Kalra, S.; Chhillar, N.
  • How long do most seizures last? A systematic comparison of seizures recorder in the epilepsy monitoring unit
    Jenssen, S.; Gracely, E.J.; Sperling, M.R.
  • The protective effect of myo-inositol on hippocamal cell loss and structural alterations in neurons and synapses triggered by kainic acid-induced status epilepticus
    Kotaria, N.; Kiladze, M.; Zhvania, M.G.; Japaridze, N.J.; Bikashvili, T.; Solomonia, R.O.; Bolkvadze, T.
  • Status epilepticus
    McCandless, D.W.
  • Chronic administration of atorvastatin induced anti-convulsant effects in mice: the role of nitric oxide
    Moezi, L.; Shafaroodi, H.; Hassanipour, M.; Fakhrzad, A.; Hassanpour, S.; Dehpour, A.R.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve Freelancer

DeepDyve Pro

Price
FREE
$49/month

$360/year
Save searches from Google Scholar, PubMed
Create lists to organize your research
Export lists, citations
Access to DeepDyve database
Abstract access only
Unlimited access to over
18 million full-text articles
Print
20 pages/month
PDF Discount
20% off