Access the full text.
Sign up today, get unlimited access with DeepDyve Pro!
is an early event in NZ‐induced apoptosis and that the release and increased activity of cathepsin D allow this protease to exert an apoptosis ‐mediating effect upstream of the caspase cascade. ...
protease , we find that the chemotherapeutic agent, etoposide, induces apoptosis and PARP proteolysis in Molt4 cells as early as 4 h with cell death lagging behind this event . In contrast, Molt4 cells ...
by the downregulation of VE-cadherin. Thus, the proatherogenic effect of CATL was partly neutralized by inducing autophagy and inhibiting apoptosis in early stages of atherosclerosis. The activation of endothelial cells ...
. At the ultrastructural level, there was damage to mitochondria and other organelles although the nuclei remained intact. Protein and RNA synthesis inhibitors as well as certain protease inhibitors protected the cells from ...
apoptosis with H2O2. We show that treatment of SH‐SY5Y cells with H2O2 up‐regulates survival pathways during early stages of apoptosis . Subsequently, the decline of anti‐apoptotic protein levels leads ...
Activation of acid and neutral sphingomyelinases, and the ensuing generation of ceramide, contributes to the biological effects of tumour necrosis factor-α (TNF-α), one of which is apoptosis . While ...
apoptosis , an effect that was prevented by pretreating the cells with NCX‐4016, NO‐naproxen, NO‐flurbiprofen, SNP or Z‐VAD.FMK, a pan‐caspase inhibitor . The activation of ICE‐like cysteine proteases ...
and forskolin, two well‐known inhibitors of CGC apoptosis , as well as by adenovirus‐mediated overexpression of Bcl‐2. 3‐Methyladenine (3‐MA) an inhibitor of autophagy, not only arrests this event but it also ...
accumulation of Hoechst 33342, DNA digestion and chromatin condensation. Zinc inhibited all of these events . An upstream event in apoptosis is activation of ICE/CED-3 proteases which is commonly observed ...
Caspases are an evolutionarily conserved family of proteases responsible for mediating and initiating cell death signals. In the past, the dysregulated activation of caspases was reported to play ...
Access the full text.
Sign up today, get unlimited access with DeepDyve Pro!