Article history: In the present study we have assessed the ability of (PAMAM) dendrimers G3 and G4 to facilitate trans- Received 28 July 2011 dermal delivery of 8-methoxypsoralen (8-MOP) in vivo. In vitro study using Franz diffusion cell revealed Accepted 19 January 2012 an enhanced transdermal ﬂux for 8-MOP in complex with G3 and G4 dendrimer in relation to standard Available online 30 January 2012 8-MOP solution. In present study in vivo skin permeation potential of 8-MOP complex with G3 and G4 PAMAM dendrimer was assessed using confocal laser scanning microscopy (CLSM), which revealed an Keywords: enhanced permeation of the 8-MOP to the deeper layers of the skin and signiﬁcantly higher concentra- PAMAM dendrimers tion in comparison with standard 8-MOP solution. Skin tissue 8-MOP concentration, evaluated by HPLC 8-MOP indicates that G3 and G4 PAMAM application signiﬁcantly increase 8-MOP skin deposition in comparison PUVA with standard 8-MOP solutions after 1 and 2 h. G4 appeared to be a more effective 8-MOP penetration Rat skin permeation enhancer than G3 PAMAM. Our results suggest the feasibility of G3 and G4 PAMAM dendrimers for trans- Confocal microscopy dermal delivery of 8-MOP resulting in better skin permeation and higher concentration of 8-MOP in
International Journal of Pharmaceutics – Elsevier
Published: Apr 15, 2012
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