Effect of polyamidoamine dendrimer G3 and G4 on skin permeation of 8-methoxypsoraleneIn vivo study

Effect of polyamidoamine dendrimer G3 and G4 on skin permeation of 8-methoxypsoraleneIn vivo study Article history: In the present study we have assessed the ability of (PAMAM) dendrimers G3 and G4 to facilitate trans- Received 28 July 2011 dermal delivery of 8-methoxypsoralen (8-MOP) in vivo. In vitro study using Franz diffusion cell revealed Accepted 19 January 2012 an enhanced transdermal flux for 8-MOP in complex with G3 and G4 dendrimer in relation to standard Available online 30 January 2012 8-MOP solution. In present study in vivo skin permeation potential of 8-MOP complex with G3 and G4 PAMAM dendrimer was assessed using confocal laser scanning microscopy (CLSM), which revealed an Keywords: enhanced permeation of the 8-MOP to the deeper layers of the skin and significantly higher concentra- PAMAM dendrimers tion in comparison with standard 8-MOP solution. Skin tissue 8-MOP concentration, evaluated by HPLC 8-MOP indicates that G3 and G4 PAMAM application significantly increase 8-MOP skin deposition in comparison PUVA with standard 8-MOP solutions after 1 and 2 h. G4 appeared to be a more effective 8-MOP penetration Rat skin permeation enhancer than G3 PAMAM. Our results suggest the feasibility of G3 and G4 PAMAM dendrimers for trans- Confocal microscopy dermal delivery of 8-MOP resulting in better skin permeation and higher concentration of 8-MOP in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Pharmaceutics Elsevier

Effect of polyamidoamine dendrimer G3 and G4 on skin permeation of 8-methoxypsoraleneIn vivo study

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Publisher
Elsevier
Copyright
Copyright © 2012 Elsevier B.V.
ISSN
0378-5173
D.O.I.
10.1016/j.ijpharm.2012.01.041
Publisher site
See Article on Publisher Site

Abstract

Article history: In the present study we have assessed the ability of (PAMAM) dendrimers G3 and G4 to facilitate trans- Received 28 July 2011 dermal delivery of 8-methoxypsoralen (8-MOP) in vivo. In vitro study using Franz diffusion cell revealed Accepted 19 January 2012 an enhanced transdermal flux for 8-MOP in complex with G3 and G4 dendrimer in relation to standard Available online 30 January 2012 8-MOP solution. In present study in vivo skin permeation potential of 8-MOP complex with G3 and G4 PAMAM dendrimer was assessed using confocal laser scanning microscopy (CLSM), which revealed an Keywords: enhanced permeation of the 8-MOP to the deeper layers of the skin and significantly higher concentra- PAMAM dendrimers tion in comparison with standard 8-MOP solution. Skin tissue 8-MOP concentration, evaluated by HPLC 8-MOP indicates that G3 and G4 PAMAM application significantly increase 8-MOP skin deposition in comparison PUVA with standard 8-MOP solutions after 1 and 2 h. G4 appeared to be a more effective 8-MOP penetration Rat skin permeation enhancer than G3 PAMAM. Our results suggest the feasibility of G3 and G4 PAMAM dendrimers for trans- Confocal microscopy dermal delivery of 8-MOP resulting in better skin permeation and higher concentration of 8-MOP in

Journal

International Journal of PharmaceuticsElsevier

Published: Apr 15, 2012

References

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