Effect of amino acids near the RGD sequence on binding activities between αIIbβ3 integrin and fibrinogen in the presence of RGD-containing synthetic peptides from elegantin and angustatin

Effect of amino acids near the RGD sequence on binding activities between αIIbβ3 integrin and... •PRGDMP-type peptides more strongly inhibited the platelet aggregation than ARGDDX-type peptides.•Cyclic peptide (CPRGDMPC) most strongly inhibited the platelet aggregation and binding between αIIbβ3 and fibrinogen.•Cyclic peptide (CPRGDMPC) demonstrated a stronger inhibitory and more stable effect in the presence of Mg2+ compared with Ca2+. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Peptides Elsevier

Effect of amino acids near the RGD sequence on binding activities between αIIbβ3 integrin and fibrinogen in the presence of RGD-containing synthetic peptides from elegantin and angustatin

Loading next page...
 
/lp/elsevier/effect-of-amino-acids-near-the-rgd-sequence-on-binding-activities-AYEElg2w0q
Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier Inc.
ISSN
0196-9781
D.O.I.
10.1016/j.peptides.2017.09.004
Publisher site
See Article on Publisher Site

Abstract

•PRGDMP-type peptides more strongly inhibited the platelet aggregation than ARGDDX-type peptides.•Cyclic peptide (CPRGDMPC) most strongly inhibited the platelet aggregation and binding between αIIbβ3 and fibrinogen.•Cyclic peptide (CPRGDMPC) demonstrated a stronger inhibitory and more stable effect in the presence of Mg2+ compared with Ca2+.

Journal

PeptidesElsevier

Published: Oct 1, 2017

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off