Exercise training has been shown to have beneficial effects on exercise performance and peripheral pathology, with improvement in the neurohumoral profile in stable patients with congestive heart failure (CHF). 1 However, the mechanisms by which exercise training improve cardiovascular function have not been fully clarified. Whether training may influence cytokine levels in such patients is unknown. In the present study we therefore evaluated the effect of a 3-month exercise training program on immunlogic mediators in patients with CHF by examining plasma cytokine levels. We also studied the relation of these changes to improvement in functional status. Recently, immunologic and inflammatory processes have been suggested to play a pathogenic role in CHF. Thus, elevated plasma levels and enhanced myocardial expression have been reported for several proinflammatory cytokines, such as tumor necrosis factor (TNF)-α and interleukin 6 in patients with CHF. 2–4 During a period from 1994 to 1996, male outpatients with symptomatic CHF were screened. Left ventricular ejection fraction was determined by radionuclide ventriculography; functional capacity was assessed by the 6-minute walk test and by the cycle ergometer exercise test with peak VO 2 determination. Only patients with exercise intolerance, confirmed by a 6-minute walk test <550 m and
The American Journal of Cardiology – Elsevier
Published: Oct 1, 2001
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