Effect of aerobic exercise training on plasma levels of tumor necrosis factor alpha in patients with heart failure

Effect of aerobic exercise training on plasma levels of tumor necrosis factor alpha in patients... Exercise training has been shown to have beneficial effects on exercise performance and peripheral pathology, with improvement in the neurohumoral profile in stable patients with congestive heart failure (CHF). 1 However, the mechanisms by which exercise training improve cardiovascular function have not been fully clarified. Whether training may influence cytokine levels in such patients is unknown. In the present study we therefore evaluated the effect of a 3-month exercise training program on immunlogic mediators in patients with CHF by examining plasma cytokine levels. We also studied the relation of these changes to improvement in functional status. Recently, immunologic and inflammatory processes have been suggested to play a pathogenic role in CHF. Thus, elevated plasma levels and enhanced myocardial expression have been reported for several proinflammatory cytokines, such as tumor necrosis factor (TNF)-α and interleukin 6 in patients with CHF. 2–4 During a period from 1994 to 1996, male outpatients with symptomatic CHF were screened. Left ventricular ejection fraction was determined by radionuclide ventriculography; functional capacity was assessed by the 6-minute walk test and by the cycle ergometer exercise test with peak VO 2 determination. Only patients with exercise intolerance, confirmed by a 6-minute walk test <550 m and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The American Journal of Cardiology Elsevier

Effect of aerobic exercise training on plasma levels of tumor necrosis factor alpha in patients with heart failure

Loading next page...
 
/lp/elsevier/effect-of-aerobic-exercise-training-on-plasma-levels-of-tumor-necrosis-I9kEgLdIK6
Publisher
Elsevier
Copyright
Copyright © 2001 Excerpta Medica Inc.
ISSN
0002-9149
D.O.I.
10.1016/S0002-9149(01)01859-8
Publisher site
See Article on Publisher Site

Abstract

Exercise training has been shown to have beneficial effects on exercise performance and peripheral pathology, with improvement in the neurohumoral profile in stable patients with congestive heart failure (CHF). 1 However, the mechanisms by which exercise training improve cardiovascular function have not been fully clarified. Whether training may influence cytokine levels in such patients is unknown. In the present study we therefore evaluated the effect of a 3-month exercise training program on immunlogic mediators in patients with CHF by examining plasma cytokine levels. We also studied the relation of these changes to improvement in functional status. Recently, immunologic and inflammatory processes have been suggested to play a pathogenic role in CHF. Thus, elevated plasma levels and enhanced myocardial expression have been reported for several proinflammatory cytokines, such as tumor necrosis factor (TNF)-α and interleukin 6 in patients with CHF. 2–4 During a period from 1994 to 1996, male outpatients with symptomatic CHF were screened. Left ventricular ejection fraction was determined by radionuclide ventriculography; functional capacity was assessed by the 6-minute walk test and by the cycle ergometer exercise test with peak VO 2 determination. Only patients with exercise intolerance, confirmed by a 6-minute walk test <550 m and

Journal

The American Journal of CardiologyElsevier

Published: Oct 1, 2001

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off