Effect of acute alcohol intoxication on the opioid system in humans

Effect of acute alcohol intoxication on the opioid system in humans We investigated the possible relation between the endogenous opioid system and acute alcoholic intoxication in 21 subjects, of whom 13 were drinkers who came to the emergency service with evident symptoms of drunkenness, and 8 were nondrinkers who consumed 1 g alcohol per kg body weight over a short period. Different patterns of changes were found in the two groups for plasma concentrations of β-endorphin and adrenocorticotropic hormone. In drinkers, plasma levels of both substances increased, whereas in nondrinkers both concentrations decreased, the declines being especially notable 15, 30, and 45 min after ingestion. We found no differences between the two groups in plasma cortisol concentrations. The different levels of these substances may reflect differences in drinking behavior between the two groups. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Alcohol Elsevier

Effect of acute alcohol intoxication on the opioid system in humans

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Publisher
Elsevier
Copyright
Copyright © 1995 Elsevier Ltd
ISSN
0741-8329
DOI
10.1016/0741-8329(95)02002-0
Publisher site
See Article on Publisher Site

Abstract

We investigated the possible relation between the endogenous opioid system and acute alcoholic intoxication in 21 subjects, of whom 13 were drinkers who came to the emergency service with evident symptoms of drunkenness, and 8 were nondrinkers who consumed 1 g alcohol per kg body weight over a short period. Different patterns of changes were found in the two groups for plasma concentrations of β-endorphin and adrenocorticotropic hormone. In drinkers, plasma levels of both substances increased, whereas in nondrinkers both concentrations decreased, the declines being especially notable 15, 30, and 45 min after ingestion. We found no differences between the two groups in plasma cortisol concentrations. The different levels of these substances may reflect differences in drinking behavior between the two groups.

Journal

AlcoholElsevier

Published: Nov 1, 1995

References

  • Importance of delta opioid receptors in maintaining high alcohol drinking
    Froehlich, J.C.; Zwifel, M.; Harts, J.; Lumeng, L.; Li, T.K.
  • Asking the right questions
    Paton, A.; Saunders, J.B.

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