Effect of a pharmacological stressor on glutamate efflux in the prefrontal cortex

Effect of a pharmacological stressor on glutamate efflux in the prefrontal cortex The anxiogenic β -carboline, FG 7142 (20 mg/kg) significantly increased glutamate efflux in the prefrontal cortex of conscious rats as assessed by microdialysis. Pretreatment with the benzodiazepine receptor agonist, diazepam (5 mg/kg), abolished this effect. These findings indicate that anxiogenic compounds produce an effect similar to physical stressors on the outflow of glutamate, and implicate the GABA/benzodiazepine receptor complex in the stress-induced activation of glutamate systems in the prefrontal cortex. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Brain Research Elsevier

Effect of a pharmacological stressor on glutamate efflux in the prefrontal cortex

Brain Research, Volume 716 (1) – Apr 15, 1996

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Publisher
Elsevier
Copyright
Copyright © 1996 Elsevier Science B.V. All rights reserved
ISSN
0006-8993
DOI
10.1016/0006-8993(96)00015-7
pmid
8738235
Publisher site
See Article on Publisher Site

Abstract

The anxiogenic β -carboline, FG 7142 (20 mg/kg) significantly increased glutamate efflux in the prefrontal cortex of conscious rats as assessed by microdialysis. Pretreatment with the benzodiazepine receptor agonist, diazepam (5 mg/kg), abolished this effect. These findings indicate that anxiogenic compounds produce an effect similar to physical stressors on the outflow of glutamate, and implicate the GABA/benzodiazepine receptor complex in the stress-induced activation of glutamate systems in the prefrontal cortex.

Journal

Brain ResearchElsevier

Published: Apr 15, 1996

References

  • Anxiogenic drugs beta-CCE and FG 7142 increase extracellular dopamine levels in nucleus accumbens
    McCullough, L.D.; Salamone, J.D.
  • Glutamatergic antagonists attenuate ability of dopamine uptake blockers to increase extracellular levels of dopamine: implications for tonic influence of glutamate on dopamine release
    Moghaddam, B.; Bolinao, M.L.
  • The GABA-ergic system: a locus of benzodiazepine action
    Tallman, J.F.; Gallager, D.W.

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