Earlier prostate-specific antigen testing in African American men—Clinical support for the recommendation

Earlier prostate-specific antigen testing in African American men—Clinical support for the... 1 Introduction</h5> In the United States, African American (AA) men are more than twice as likely to die of prostate cancer as white men are [1] . Racial disparities in prostate cancer mortality have been associated with AA men having reduced access to prostate cancer screening services and less timely receipt of quality health care than white men are [2–5] . Racial differences in prostate tumor biology have also been observed, but reported studies may be biased by socioeconomic, educational, and cultural variables [6] . When clinicopathologic features of prostate cancers at diagnosis in AA men are compared with white men in general population studies, the following racial disparities are observed: (1) higher tumor grade, (2) greater likelihood of nonlocalized, advanced-stage prostate cancer, (3) higher tumor volume in radical prostatectomy specimens, (4) higher index prostate-specific antigen (PSA) levels, and (5) less likelihood of being in a low-risk prognostic strata [7] . Limited data are available regarding prostate cancer screening outcomes in AA men and whether racial differences in tumor biology exist when equal insurance coverage is available [8–10] . Prostate screening guidelines identify AA men as a high-risk group and recommend PSA testing at an early age for http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Urologic Oncology: Seminars and Original Investigations Elsevier

Earlier prostate-specific antigen testing in African American men—Clinical support for the recommendation

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Publisher
Elsevier
Copyright
Copyright © 2015 Elsevier Inc.
ISSN
1078-1439
D.O.I.
10.1016/j.urolonc.2015.03.018
Publisher site
See Article on Publisher Site

Abstract

1 Introduction</h5> In the United States, African American (AA) men are more than twice as likely to die of prostate cancer as white men are [1] . Racial disparities in prostate cancer mortality have been associated with AA men having reduced access to prostate cancer screening services and less timely receipt of quality health care than white men are [2–5] . Racial differences in prostate tumor biology have also been observed, but reported studies may be biased by socioeconomic, educational, and cultural variables [6] . When clinicopathologic features of prostate cancers at diagnosis in AA men are compared with white men in general population studies, the following racial disparities are observed: (1) higher tumor grade, (2) greater likelihood of nonlocalized, advanced-stage prostate cancer, (3) higher tumor volume in radical prostatectomy specimens, (4) higher index prostate-specific antigen (PSA) levels, and (5) less likelihood of being in a low-risk prognostic strata [7] . Limited data are available regarding prostate cancer screening outcomes in AA men and whether racial differences in tumor biology exist when equal insurance coverage is available [8–10] . Prostate screening guidelines identify AA men as a high-risk group and recommend PSA testing at an early age for

Journal

Urologic Oncology: Seminars and Original InvestigationsElsevier

Published: Jul 1, 2015

References

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