The effects of intracerebroventricular administration of dynorphin A-(1–13) on scopolamine-induced amnesia were investigated in mice by using a step-down type passive avoidance task. The pre- or post-training, or pre-retention administration of dynorphin A-(1–13) (0.3–10 μg) alone failed to affect steo-down latency of the passive avoidance response, while scopolamine (1 mg/kg) significantly shortened step-down latency. Dynorphin A-(1–13) (1 μg) given 15 min before training and retention tests but not immediately after training significantly improved the scopolamine (1 mg/kg)-induced shortening of step-down latency of the passive avoidance response, indicating antiamnesic effects of dynorphin A-(1–13) (1 μg). A lower dose (1 mg/kg) of the κ-opioid receptor antagonist, (−)-(1 R ,5 R ,9 R )-5,9-diethyl-2-(3-furyl-methyl)-2′-hydroxy-6,7-benzomorphan, reversed the antiamnesic effects of dynorphin A-(1–13) (1 μg). These results suggest that the antiamnesic effects of dynorphin A-(1–13) depend on the timing of drug treatments.
European Journal of Pharmacology – Elsevier
Published: Feb 14, 1995
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