International Journal of Pharmaceutics 563 (2019) 373–383 Contents lists available at ScienceDirect International Journal of Pharmaceutics journal homepage: www.elsevier.com/locate/ijpharm Dynamics of water and xanthan chains in hydrogels studied by NMR relaxometry and their inﬂuence on drug release a, a a b a Urša Mikac , Ana Sepe , Anton Gradišek , Julijana Kristl , Tomaž Apih Jožef Stefan Institute, Ljubljana, Slovenia University of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia ARTIC L E I NF O ABSTRAC T This study is dedicated to the memory of The dynamic properties of water and polymer molecules in xanthan hydrogels at diﬀerent polymer mass frac- Professor Saša Baumgartner, whose NMR tions were investigated through the combination of conventional and fast-ﬁeld cycling NMR relaxation to obtain studies of hydrophilic matrix tablets led her to the information about dynamics in diﬀerent time scales. The results showed that water dynamics were faster in conceive and start this study before she was lost diluted than in concentrated hydrogels. However, the type of polymer-chain dynamics did not change for to us. xanthan fractions from 0.1 to 0.5, although they slowed at higher xanthan fractions as the system approached Keywords: transition to the glass state. The addition of the
International Journal of Pharmaceutics – Elsevier
Published: May 30, 2019
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