Dynamics of water and xanthan chains in hydrogels studied by NMR relaxometry and their influence on drug release

Dynamics of water and xanthan chains in hydrogels studied by NMR relaxometry and their influence... International Journal of Pharmaceutics 563 (2019) 373–383 Contents lists available at ScienceDirect International Journal of Pharmaceutics journal homepage: www.elsevier.com/locate/ijpharm Dynamics of water and xanthan chains in hydrogels studied by NMR relaxometry and their influence on drug release a, a a b a Urša Mikac , Ana Sepe , Anton Gradišek , Julijana Kristl , Tomaž Apih Jožef Stefan Institute, Ljubljana, Slovenia University of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia ARTIC L E I NF O ABSTRAC T This study is dedicated to the memory of The dynamic properties of water and polymer molecules in xanthan hydrogels at different polymer mass frac- Professor Saša Baumgartner, whose NMR tions were investigated through the combination of conventional and fast-field cycling NMR relaxation to obtain studies of hydrophilic matrix tablets led her to the information about dynamics in different time scales. The results showed that water dynamics were faster in conceive and start this study before she was lost diluted than in concentrated hydrogels. However, the type of polymer-chain dynamics did not change for to us. xanthan fractions from 0.1 to 0.5, although they slowed at higher xanthan fractions as the system approached Keywords: transition to the glass state. The addition of the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Pharmaceutics Elsevier

Dynamics of water and xanthan chains in hydrogels studied by NMR relaxometry and their influence on drug release

Loading next page...
 
/lp/elsevier/dynamics-of-water-and-xanthan-chains-in-hydrogels-studied-by-nmr-B89rJXLu7j
Publisher site
See Article on Publisher Site

Abstract

International Journal of Pharmaceutics 563 (2019) 373–383 Contents lists available at ScienceDirect International Journal of Pharmaceutics journal homepage: www.elsevier.com/locate/ijpharm Dynamics of water and xanthan chains in hydrogels studied by NMR relaxometry and their influence on drug release a, a a b a Urša Mikac , Ana Sepe , Anton Gradišek , Julijana Kristl , Tomaž Apih Jožef Stefan Institute, Ljubljana, Slovenia University of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia ARTIC L E I NF O ABSTRAC T This study is dedicated to the memory of The dynamic properties of water and polymer molecules in xanthan hydrogels at different polymer mass frac- Professor Saša Baumgartner, whose NMR tions were investigated through the combination of conventional and fast-field cycling NMR relaxation to obtain studies of hydrophilic matrix tablets led her to the information about dynamics in different time scales. The results showed that water dynamics were faster in conceive and start this study before she was lost diluted than in concentrated hydrogels. However, the type of polymer-chain dynamics did not change for to us. xanthan fractions from 0.1 to 0.5, although they slowed at higher xanthan fractions as the system approached Keywords: transition to the glass state. The addition of the

Journal

International Journal of PharmaceuticsElsevier

Published: May 30, 2019

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off