Access the full text.
Sign up today, get unlimited access with DeepDyve Pro!
of the pathogenic mechanisms involved in IBD. IL-25, a cytokine belonging to the IL-17 family, starts and promotes the Th2 responses and inhibits the Th1 and Th17 responses.13 It seems to exert two distinct ...
/ Th17 cell-driven colitis support the key role of IL-21 in positively regulating Th1 and Th17 cell-associated inflammatory pathways (Fig. 2 ).49 Figure 2 . View largeDownload slide IL-21 is a potent ...
to enteric antigens. These T cells can include Th1 cells, which produce IFNγ; Th17 cells, which produce IL-17; or Th2 cells, which produce IL-4, IL-5, or IL-13 (see Fig. 2 ). A recent pediatric study has ...
infections, can be classified in subsets of Th1 , Th2 , Th17 , Th22, follicular helper (Tfh), and regulatory T-cells (Treg) based on their phenotypes, cytokine production, transcriptional profiles and anatomic ...
of defense against infection but also via cytokine production and antigen presentation help bridge to specific immune protection through induction and activation of T cells and the adaptive immune system. 2 ...
component 1q- binding protein −1.84 −2.41 MASP2 Mannan-binding lectin serine protease 2 −1.20 2.99 2.06 DEFB1 Defensin , beta 1 −4.50 HPGD Hydroxyprostaglandin dehydrogenase 15-(NAD) 2.38 LILRB1 Leucocyte ...
by specific human defensins . Indeed, transgenic expression of human defensin 5 in mice leads to a lack of SFB colonization and a subsequent elimination of Th17 cells in the intestinal LP.154 One report suggests ...
Defensins are antimicrobial peptides involved in innate defense mechanisms. The probiotic E. coli Nissle strain induced expression of human beta - defensin 2 (hBD- 2 ) in Caco- 2 intestinal epithelial cells42 ...
helper (Th) cell response by the adaptive immune system leads to tissue-specific inflammation. The now outdated Th1 / Th2 classification has been superseded by a multitude of T-cell lineages including iTregs ...
states that determine their function, phenotype, and capacity for persistence. These polarization states include Th1 , Th2 , Th17 , and T-regulatory (Treg) cells. Briefly, Th1 , Th2 , and Th17 cells ...
Access the full text.
Sign up today, get unlimited access with DeepDyve Pro!