Dry powder inhalers of gentamicin and leucine: formulation parameters, aerosol performance and in vitro toxicity on CuFi1 cells

Dry powder inhalers of gentamicin and leucine: formulation parameters, aerosol performance and in... Article history: The high hygroscopicity of gentamicin (G) as raw material hampers the production of respirable parti- Received 17 November 2011 cles during aerosol generation and prevents its direct use as powder for inhalation in patients suffering Received in revised form 12 January 2012 from cystic fibrosis (CF). Therefore, this research aimed to design a new dry powder formulation of G Accepted 13 January 2012 studying dispersibility properties of an aminoacid, l-leucine (leu), and appropriate process conditions. Available online 23 January 2012 Spray-dried powders were characterized as to water uptake, particle size distribution, morphology and stability, in correlation with process parameters. Aerodynamic properties were analyzed both by Single Keywords: Stage Glass Impinger and Andersen Cascade Impactor. Moreover, the potential cytotoxicity on bronchial Cystic fibrosis epithelial cells bearing a CFTR F508/F508 mutant genotype (CuFi1) were tested. Results indicated that Gentamicin sulfate leu may improve the aerosol performance of G-dried powders. The maximum fine particle fraction (FPF) l-leucine of about 58.3% was obtained when water/isopropyl alcohol 7:3 system and 15–20% (w/w) of leu were Spray drying Dry powder inhaler used, compared to a FPF value of 13.4% for neat G-dried powders. The enhancement of aerosol efficiency CF airway epithelial cells was http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Pharmaceutics Elsevier

Dry powder inhalers of gentamicin and leucine: formulation parameters, aerosol performance and in vitro toxicity on CuFi1 cells

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Publisher
Elsevier
Copyright
Copyright © 2012 Elsevier B.V.
ISSN
0378-5173
D.O.I.
10.1016/j.ijpharm.2012.01.026
Publisher site
See Article on Publisher Site

Abstract

Article history: The high hygroscopicity of gentamicin (G) as raw material hampers the production of respirable parti- Received 17 November 2011 cles during aerosol generation and prevents its direct use as powder for inhalation in patients suffering Received in revised form 12 January 2012 from cystic fibrosis (CF). Therefore, this research aimed to design a new dry powder formulation of G Accepted 13 January 2012 studying dispersibility properties of an aminoacid, l-leucine (leu), and appropriate process conditions. Available online 23 January 2012 Spray-dried powders were characterized as to water uptake, particle size distribution, morphology and stability, in correlation with process parameters. Aerodynamic properties were analyzed both by Single Keywords: Stage Glass Impinger and Andersen Cascade Impactor. Moreover, the potential cytotoxicity on bronchial Cystic fibrosis epithelial cells bearing a CFTR F508/F508 mutant genotype (CuFi1) were tested. Results indicated that Gentamicin sulfate leu may improve the aerosol performance of G-dried powders. The maximum fine particle fraction (FPF) l-leucine of about 58.3% was obtained when water/isopropyl alcohol 7:3 system and 15–20% (w/w) of leu were Spray drying Dry powder inhaler used, compared to a FPF value of 13.4% for neat G-dried powders. The enhancement of aerosol efficiency CF airway epithelial cells was

Journal

International Journal of PharmaceuticsElsevier

Published: Apr 15, 2012

References

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