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Necl‐5, known as a poliovirus receptor and up‐ regulated in many cancer cells, enhances platelet‐derived growth factor (PDGF)‐induced activation of Ras‐Raf‐MEK‐ERK signaling, but not PDGF‐induced ...
growth factor form a complex and cooperate to down - regulate the acti- (TGF ) coordinates physiological responses in di- vated type I receptor ALK5. We further show that both the S verse cell types ...
growth factor receptor (EGFR)-Cbl interactions and EGFR down - regulation . To further examine the link between the hyperactivation of Cdc42 and its ability to alter EGFR signaling and thereby cause cellular ...
Growth Factor Leads to Negative Regulation of Type I Receptor Signaling in Cooperation with the Smurf2 □ S Ubiquitin Ligase Received for publication, September 23, 2011, and in revised form, February 23 ...
KLF4 (Krüppel-like factor 4) has been implicated in vascular smooth muscle cell (VSMC) differentiation induced by transforming growth factor β (TGF-β). However, the role of KLF4 and mechanism ...
Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland, USA Key Words. Hematopoietic regulation Transforming growth factor -/l Receptor modulation Cytokines Hematopoiesis ...
Abstract Signaling from transforming growth factor -β (TGF-β) through its unique transmembrane receptor serine–threonine kinases plays a complex role in carcinogenesis, having both tumor suppressor ...
by overexpression of at least one member of this growth factor receptor family (c‐erbB‐1 to c‐erbB‐4) inducing cell growth in the absence of ligand stimulation and leading to malignant transformation , human breast ...
The transforming growth factor beta (TGFβ) and Wnt signaling pathways play central roles regulating embryogenesis and maintaining adult tissue homeostasis. TGFβ mediates its cellular effects through ...
. Blood 1990 ; 76 : 323 – 329 . Google Scholar Crossref Search ADS PubMed WorldCat 11 Keller JR , Jacobsen SEW, Dubois CM, Hestdal K, Ruscetti FW. Transforming growth factor -β: a bidirectional regulator ...
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