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spectrometry (AMS). Assessment of the kinetics of hepatic MeIQx DNA adduct formation over 42 days (1.1×10-4 mg [2-14C]MeIQx kg daily dose ) shows that steady-state [2-14C]MeIQx tissue concentrations of 138 ± 15 ...
The formation of N7-(2-hydroxyethyl)guanine (7-HEG) in DNA was investigated previously in target and non-target tissues of F-344 rats and B6C3F1 mice exposed to ≥ISOdia≥10 p.p.m. concentrations ...
by HPLC separation and fluorescence detection. HEtVal formation was linear between 3 and 33 ppm ETO and increased in slope above 33 ppm. The dose - response curves for 7-HEG in rat tissues were linear between ...
dacarbazine and compared with those observed in various tissues of rodents treated with different doses of the drug. In Hodgkin's lymphoma patients adduct levels reached a value of 0.27± 0.14 fmol/μg DNA 2 h ...
dacarbazine and comparedwith those observed in various tissues of rodents treated with different dosesof the drug. In Hodgkin's lymphoma patients adduct levels reached a value of0.27± 0.14 fmol/μg DNA 2 h after ...
formation and (ii) available dose – response data for tumour induction, both in the same target tissue , the liver, for the same species, the rat , and for the same gender. In vivo DNA adduct formation data were ...
and the formation of DNA and hemoglobin (HGB) adducts . AA was administered to CYP2E1-null or wild-type mice at 50 mg/kg ip. Mice were euthanized 6 h later and blood and tissues were collected. Using LC-ES/MS/MS, AA ...
, liver and skin. We undertook these studies to determine whether tissue specificity for DBC lung carcinogenicity inthe strain A/J mouse is mirrored by formation of DBC- DNA adducts in lung tissue ...
with the adduct levels in extrahepatic tissues (remaining columns). Open in new tab Impact of the SULT status on the formation of DNA adducts in four tissues of mice treated with methyleugenol at a dose of 50 mg kg ...
the formation of DNA adducts is a potential key event during carcinogenesis, it is important to keep the dose - response for both exogenous and endogenous DNA adducts from formaldehyde in perspective. Considerable ...
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