Dorsal and ventral hippocampal cholinergic systems modulate anxiety in the plus-maze and shock-probe tests

Dorsal and ventral hippocampal cholinergic systems modulate anxiety in the plus-maze and... There is emerging evidence that increased acetylcholine levels in brain reduce anxiety. More specifically there is evidence that some of these anxiolytic effects of acetylcholine are modulated by the hippocampus. In the present study we examined the roles of the cholinergic systems in the dorsal and ventral hippocampus in two animal models of anxiety: the elevated plus-maze and the shock-probe burying tests. We found that microinfusions (10 μg/0.5 μl) of the acetylcholinesterase inhibitor physostigmine in either the dorsal or the ventral hippocampus increased rats’ open arm exploration in the plus-maze test, and decreased burying behavior in the shock-probe test. Interestingly, infusions in the ventral, but not the dorsal hippocampus also increased the number of contacts rats made with the shock-probe. Overall, the results suggest that cholinergic stimulation in the dorsal and ventral hippocampus modulate anxiety, but that only the ventral hippocampal cholinergic system is involved in the passive avoidance of painful stimuli. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Brain Research Elsevier

Dorsal and ventral hippocampal cholinergic systems modulate anxiety in the plus-maze and shock-probe tests

Brain Research, Volume 949 (1) – Sep 13, 2002

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Publisher
Elsevier
Copyright
Copyright © 2002 Elsevier Science B.V.
ISSN
0006-8993
DOI
10.1016/S0006-8993(02)02965-7
Publisher site
See Article on Publisher Site

Abstract

There is emerging evidence that increased acetylcholine levels in brain reduce anxiety. More specifically there is evidence that some of these anxiolytic effects of acetylcholine are modulated by the hippocampus. In the present study we examined the roles of the cholinergic systems in the dorsal and ventral hippocampus in two animal models of anxiety: the elevated plus-maze and the shock-probe burying tests. We found that microinfusions (10 μg/0.5 μl) of the acetylcholinesterase inhibitor physostigmine in either the dorsal or the ventral hippocampus increased rats’ open arm exploration in the plus-maze test, and decreased burying behavior in the shock-probe test. Interestingly, infusions in the ventral, but not the dorsal hippocampus also increased the number of contacts rats made with the shock-probe. Overall, the results suggest that cholinergic stimulation in the dorsal and ventral hippocampus modulate anxiety, but that only the ventral hippocampal cholinergic system is involved in the passive avoidance of painful stimuli.

Journal

Brain ResearchElsevier

Published: Sep 13, 2002

References

  • Hippocampal formation
    Amaral, D.G.; Witter, M.P.
  • Hippocampal cholinergic blockade enhances hypothalamic–pituitary–adrenal responses to stress
    Bhatnagar, S.; Costall, B.; Smythe, J.W.
  • Septal GABAergic and hippocampal cholinergic systems modulate anxiety in the plus-maze and shock-probe tests
    Degroot, A.; Kashluba, S.; Treit, D.
  • Collateral projections from the median raphe nucleus to the medial septum and hippocampus
    Mckenna, J.T.; P Vertes, R.
  • The central and basolateral amygdala differentially mediate the anxiolytic effects of benzodiazepines
    Pesold, C.; Treit, D.
  • Factor analysis of spatiotemporal and ethological measures in the murine elevated plus-maze test of anxiety
    Rodgers, R.J.; Johnson, N.J.
  • Muscarinic antagonists are anxiogenic in rats tested in the black–white box
    Smythe, J.W.; Murphy, D.; Bhatnagar, S.; Timothy, C.; Costall, B.
  • The effects of intrahippocampal scopolamine infusions on anxiety in rats as measured by the black–white box test
    Smythe, J.W.; Murphy, D.; Bhatnagar, S.; Timothy, C.; Costall, B.
  • The anxiolytic-like effect of nicotine undergoes rapid tolerance in a model of contextual fear conditioning in rats
    Szyndler, J.; Sienkiewicz-Jarosz, H.; Maciejal, P.; Siemiatkowski, M.; Rokicki, D.; Czlonkowska, A.I.; Plaznik, A.
  • Effects of intrahippocampal injections of the cholinergic neurotoxin AF64A on presynaptic cholinergic markers and on passive avoidance response in the rat
    Tateishi, N.; Takano, Y.; Honda, K.; Yamada, K.; Kamiya, Y.; Kamiya, H.

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