Dopamine receptors in the striatum of rats exposed to repeated restraint stress and alprazolam treatment

Dopamine receptors in the striatum of rats exposed to repeated restraint stress and alprazolam... Stress-related behaviors are accompanied by modification of a large number of neurotransmitters in the brain. Moreover, the binding to GABA A receptors does not account for all the effects of benzodiazepines. In this study we investigated the effect of repeated restraint stress and alprazolam treatment (1 mg/day os) on dopamine receptors ( B max and K d ) in the striatum of adult rats by means of quantitative receptor autoradiography. After chronic restraint stress dopamine D 1 receptors ( B max value) decreased in the accumbens nucleus, whereas dopamine D 2 receptors were not modified in any investigated area. After alprazolam treatment, a considerable increase in both dopamine D 1 and D 2 receptors in the striatum was observed. Chronic immobilization stress together with alprazolam treatment re-established dopamine D 1 receptor density to control values in the accumbens nucleus and olfactory tubercle, whereas it resulted in an increase in dopamine D 2 receptors comparable to that elicited by alprazolam treatment alone. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Pharmacology Elsevier

Dopamine receptors in the striatum of rats exposed to repeated restraint stress and alprazolam treatment

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Publisher
Elsevier
Copyright
Copyright © 1998 Elsevier Science B.V.
ISSN
0014-2999
DOI
10.1016/S0014-2999(97)01608-7
Publisher site
See Article on Publisher Site

Abstract

Stress-related behaviors are accompanied by modification of a large number of neurotransmitters in the brain. Moreover, the binding to GABA A receptors does not account for all the effects of benzodiazepines. In this study we investigated the effect of repeated restraint stress and alprazolam treatment (1 mg/day os) on dopamine receptors ( B max and K d ) in the striatum of adult rats by means of quantitative receptor autoradiography. After chronic restraint stress dopamine D 1 receptors ( B max value) decreased in the accumbens nucleus, whereas dopamine D 2 receptors were not modified in any investigated area. After alprazolam treatment, a considerable increase in both dopamine D 1 and D 2 receptors in the striatum was observed. Chronic immobilization stress together with alprazolam treatment re-established dopamine D 1 receptor density to control values in the accumbens nucleus and olfactory tubercle, whereas it resulted in an increase in dopamine D 2 receptors comparable to that elicited by alprazolam treatment alone.

Journal

European Journal of PharmacologyElsevier

Published: Mar 5, 1998

References

  • Selective activation of dopamine transmission in the shell of the nucleus accumbens by stress
    Kalivas, P.W.; Duffy, P.
  • Acute effects of alprazolam and adinazolam on the concentrations of corticotropin-releasing factor in the rat brain
    Owens, M.J.; Bissette, G.; Nemeroff, C.B.
  • Behavioral, neurochemical, anatomical and electrophysiological correlates of panic disorder: multiple transmitter interaction and neuropeptide colocalization
    Zacharko, R.M.; Koszycki, D.; Mendella, P.D.; Bradwejn, J.

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