Dopamine antagonism attenuates the unconditioned incentive value of estrous female cues

Dopamine antagonism attenuates the unconditioned incentive value of estrous female cues The role of dopaminergic transmission in the incentive–motivational processes involved in the generation of male sexual behavior was examined. Three groups of sexually naı̈ve Long–Evans male rats traversed a straight alley for one of three goalbox targets: an empty goalbox, a nonestrous female, or an estrous female. A Plexiglas partition within the goalbox allowed for the perception of visual, auditory, and olfactory cues, but prevented physical contact. Baseline run times revealed that subjects returned to the goalbox significantly faster for an estrous female than for a nonestrous female, replicating our earlier work on the inherent incentive value of primary female cues. When subjects were then pretreated with the dopamine receptor antagonist, haloperidol (0.0, 0.075, or 0.15 mg/kg), they expressed decreased sexual motivation as reflected by increased run times for estrous female targets. Subjects' run times for the empty goalbox condition were unaffected by haloperidol, suggesting that the drug did not reliably impair motoric capacity. Results support the contention that central dopaminergic systems are involved in the regulation of the positive, unconditioned incentive value of estrous female cues. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmacology Biochemistry and Behavior Elsevier

Dopamine antagonism attenuates the unconditioned incentive value of estrous female cues

Loading next page...
 
/lp/elsevier/dopamine-antagonism-attenuates-the-unconditioned-incentive-value-of-WAAtdGlQuQ
Publisher
Elsevier
Copyright
Copyright © 2001 Elsevier Science Inc.
ISSN
0091-3057
eISSN
1873-5177
D.O.I.
10.1016/S0091-3057(00)00472-X
Publisher site
See Article on Publisher Site

Abstract

The role of dopaminergic transmission in the incentive–motivational processes involved in the generation of male sexual behavior was examined. Three groups of sexually naı̈ve Long–Evans male rats traversed a straight alley for one of three goalbox targets: an empty goalbox, a nonestrous female, or an estrous female. A Plexiglas partition within the goalbox allowed for the perception of visual, auditory, and olfactory cues, but prevented physical contact. Baseline run times revealed that subjects returned to the goalbox significantly faster for an estrous female than for a nonestrous female, replicating our earlier work on the inherent incentive value of primary female cues. When subjects were then pretreated with the dopamine receptor antagonist, haloperidol (0.0, 0.075, or 0.15 mg/kg), they expressed decreased sexual motivation as reflected by increased run times for estrous female targets. Subjects' run times for the empty goalbox condition were unaffected by haloperidol, suggesting that the drug did not reliably impair motoric capacity. Results support the contention that central dopaminergic systems are involved in the regulation of the positive, unconditioned incentive value of estrous female cues.

Journal

Pharmacology Biochemistry and BehaviorElsevier

Published: Mar 1, 2001

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off