10.1016/j.mehy.2017.07.014

10.1016/j.mehy.2017.07.014 Medical Hypotheses 107 (2017) 16–21 Contents lists available at ScienceDirect Medical Hypotheses journal homepage: www.elsevier.com/locate/mehy Do some epithelial ovarian cancers originate from a fallopian tube ciliate cell lineage? a,b,⇑ c b Jan Rohozinski , Conception Diaz-Arrastia , Creighton L. Edwards Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA Division of Gynecologic Oncology, Departments of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA University of Texas, Memorial Hermann Cancer Center – Texas Medical Center, 6400 Fannin St, Suite 2900, Houston, TX 77030, USA ar ti c l e i nf o ab stra ct Article history: There is a general agreement that a large subpopulation of serous ovarian cancers arise from the fallopian Received 6 March 2017 tube mucosal epithelium. However, there is still some debate as to whether the cancers originate from a Accepted 15 July 2017 secretory or ciliate cell lineage. One well established method for determining the origin of a cell line is to document the expression of genes and proteins that are cell type specific. Lineage or tissue specific pat- terns of gene expression are evidence of direct decent from a given cell type within a tissue. It http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

10.1016/j.mehy.2017.07.014

Elsevier — Jun 11, 2020

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Medical Hypotheses 107 (2017) 16–21 Contents lists available at ScienceDirect Medical Hypotheses journal homepage: www.elsevier.com/locate/mehy Do some epithelial ovarian cancers originate from a fallopian tube ciliate cell lineage? a,b,⇑ c b Jan Rohozinski , Conception Diaz-Arrastia , Creighton L. Edwards Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA Division of Gynecologic Oncology, Departments of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA University of Texas, Memorial Hermann Cancer Center – Texas Medical Center, 6400 Fannin St, Suite 2900, Houston, TX 77030, USA ar ti c l e i nf o ab stra ct Article history: There is a general agreement that a large subpopulation of serous ovarian cancers arise from the fallopian Received 6 March 2017 tube mucosal epithelium. However, there is still some debate as to whether the cancers originate from a Accepted 15 July 2017 secretory or ciliate cell lineage. One well established method for determining the origin of a cell line is to document the expression of genes and proteins that are cell type specific. Lineage or tissue specific pat- terns of gene expression are evidence of direct decent from a given cell type within a tissue. It

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