Do selective serotonin reuptake inhibitors improve survival in multiple system atrophy?

Do selective serotonin reuptake inhibitors improve survival in multiple system atrophy? IntroductionLoss of brainstem serotonergic neurons in MSA patients is implicated in respiratory dysfunction including stridor and may increase the risk of sudden death. Augmenting serotonergic transmission through selective serotonergic reuptake inhibitors (SSRIs) has been proposed to improve stridor and prolong survival in multiple system atrophy (MSA). We sought to determine whether MSA patients on an SSRI during their disease course have improved survival compared to those not on an SSRI. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Parkinsonism & Related Disorders Elsevier

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier Ltd
ISSN
1353-8020
D.O.I.
10.1016/j.parkreldis.2017.12.011
Publisher site
See Article on Publisher Site

Abstract

IntroductionLoss of brainstem serotonergic neurons in MSA patients is implicated in respiratory dysfunction including stridor and may increase the risk of sudden death. Augmenting serotonergic transmission through selective serotonergic reuptake inhibitors (SSRIs) has been proposed to improve stridor and prolong survival in multiple system atrophy (MSA). We sought to determine whether MSA patients on an SSRI during their disease course have improved survival compared to those not on an SSRI.

Journal

Parkinsonism & Related DisordersElsevier

Published: Mar 1, 2018

References

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