DNA replication and inter-strand crosslink repair: Symmetric activation of dimeric nanomachines?

DNA replication and inter-strand crosslink repair: Symmetric activation of dimeric nanomachines? Eukaryotic DNA replication initiation and the Fanconi anemia pathway of interstrand crosslink repair both revolve around the recruitment of a set of DNA-processing factors onto a dimeric protein complex, which functions as a loading platform (MCM and FANCI-FANCD2 respectively). Here we compare and contrast the two systems, identifying a set of unresolved mechanistic questions. How is the dimeric loading platform assembled on the DNA? How can equivalent covalent modification of both factors in a dimer be achieved? Are multicomponent DNA-interacting machines built symmetrically around their dimeric loading platform? Recent biochemical reconstitution studies are starting to shed light on these issues. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biophysical Chemistry Elsevier

DNA replication and inter-strand crosslink repair: Symmetric activation of dimeric nanomachines?

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Publisher
Elsevier
Copyright
Copyright © 2016 Elsevier Ltd
ISSN
0301-4622
D.O.I.
10.1016/j.bpc.2016.11.001
Publisher site
See Article on Publisher Site

Abstract

Eukaryotic DNA replication initiation and the Fanconi anemia pathway of interstrand crosslink repair both revolve around the recruitment of a set of DNA-processing factors onto a dimeric protein complex, which functions as a loading platform (MCM and FANCI-FANCD2 respectively). Here we compare and contrast the two systems, identifying a set of unresolved mechanistic questions. How is the dimeric loading platform assembled on the DNA? How can equivalent covalent modification of both factors in a dimer be achieved? Are multicomponent DNA-interacting machines built symmetrically around their dimeric loading platform? Recent biochemical reconstitution studies are starting to shed light on these issues.

Journal

Biophysical ChemistryElsevier

Published: Jun 1, 2017

References

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