DNA Nanostructures as Smart Drug-Delivery Vehicles and Molecular Devices

DNA Nanostructures as Smart Drug-Delivery Vehicles and Molecular Devices DNA molecules can be assembled into custom predesigned shapes via hybridization of sequence-complementary domains. The folded structures have high spatial addressability and a tremendous potential to serve as platforms and active components in a plethora of bionanotechnological applications. DNA is a truly programmable material, and its nanoscale engineering thus opens up numerous attractive possibilities to develop novel methods for therapeutics. The tailored molecular devices could be used in targeting cells and triggering the cellular actions in the biological environment. In this review we focus on the DNA-based assemblies – primarily DNA origami nanostructures – that could perform complex tasks in cells and serve as smart drug-delivery vehicles in, for example, cancer therapy, prodrug medication, and enzyme replacement therapy. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Trends in Biotechnology Elsevier

DNA Nanostructures as Smart Drug-Delivery Vehicles and Molecular Devices

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Publisher
Elsevier Current Trends
Copyright
Copyright © 2015 Elsevier Ltd
ISSN
0167-7799
D.O.I.
10.1016/j.tibtech.2015.08.001
Publisher site
See Article on Publisher Site

Abstract

DNA molecules can be assembled into custom predesigned shapes via hybridization of sequence-complementary domains. The folded structures have high spatial addressability and a tremendous potential to serve as platforms and active components in a plethora of bionanotechnological applications. DNA is a truly programmable material, and its nanoscale engineering thus opens up numerous attractive possibilities to develop novel methods for therapeutics. The tailored molecular devices could be used in targeting cells and triggering the cellular actions in the biological environment. In this review we focus on the DNA-based assemblies – primarily DNA origami nanostructures – that could perform complex tasks in cells and serve as smart drug-delivery vehicles in, for example, cancer therapy, prodrug medication, and enzyme replacement therapy.

Journal

Trends in BiotechnologyElsevier

Published: Oct 1, 2015

References

  • The enabled state of DNA nanotechnology
    Linko, V.; Dietz, H.
  • Self-assembly of a nanoscale DNA box with a controllable lid
    Andersen, E.S.
  • Complex shapes self-assembled from single-stranded DNA tiles
    Wei, B.
  • DNA rendering of polyhedral meshes at the nanoscale
    Benson, E.
  • Functionalization of DNA nanostructures with proteins
    Saccà, B.; Niemeyer, C.M.
  • DNA nanotubes as intracellular delivery vehicles in vivo
    Sellner, S.
  • Sequence-responsive unzipping DNA cubes with tunable cellular uptake profiles
    Bujold, K.E.
  • Design, assembly, and activity of antisense DNA nanostructures
    Keum, J-W.
  • Quantification of cellular uptake of DNA nanostructures by qPCR
    Okholm, A.H.
  • Designed intercalators for modification of DNA origami surface properties
    Brglez, J.
  • Virus-based nanocarriers for drug delivery
    Ma, Y.
  • DNA-based assembly lines and nanofactories
    Simmel, F.C.

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