DNA fragmentation in granular cells of human cerebellum following global ischemia

DNA fragmentation in granular cells of human cerebellum following global ischemia Vulnerability of human cerebellum in two autopsy cases following global brain ischemia was examined histologically by using a specific in situ nick-end labeling method for DNA breaks. In both cases, DNA fragmentation was observed in approximately one-third of the granular cells in cerebellar cortex, whereas Purkinje cells were still alive and no DNA fragmentation was recognized in the nuclei. The present study suggests that some granular cells of cerebellar cortex are more vulnerable to transient ischemia than Purkinje cells and death of granular cells in induced by an apoptotic DNA fragmentation following global brain ischemia. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Brain Research Elsevier

DNA fragmentation in granular cells of human cerebellum following global ischemia

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Publisher
Elsevier
Copyright
Copyright © 1995 Elsevier Science B.V. All rights reserved
ISSN
0006-8993
D.O.I.
10.1016/0006-8993(95)00902-3
Publisher site
See Article on Publisher Site

Abstract

Vulnerability of human cerebellum in two autopsy cases following global brain ischemia was examined histologically by using a specific in situ nick-end labeling method for DNA breaks. In both cases, DNA fragmentation was observed in approximately one-third of the granular cells in cerebellar cortex, whereas Purkinje cells were still alive and no DNA fragmentation was recognized in the nuclei. The present study suggests that some granular cells of cerebellar cortex are more vulnerable to transient ischemia than Purkinje cells and death of granular cells in induced by an apoptotic DNA fragmentation following global brain ischemia.

Journal

Brain ResearchElsevier

Published: Oct 30, 1995

References

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