DLX1, a binding protein of beta-catenin, promoted the growth and migration of prostate cancer cells

DLX1, a binding protein of beta-catenin, promoted the growth and migration of prostate cancer cells Several studies have indicated the involvement of DLX1 in the progression of prostate cancer. However, the functions of DLX1 in the prostate cancer and the underlying molecular mechanism remains largely unknown. In this study, we have shown that DLX1 was up-regulated in the prostate clinical samples. DLX1 promoted the growth, migration and colony formation of prostate cancer cells by activating beta-catenin/TCF signaling. DLX1 interacted with beta-catenin and enhanced the interaction between beta-catenin and TCF4. Taken together, this study demonstrated that DLX1 exerted the oncogenic roles on the prostate cancer by activating beta-catenin/TCF signaling. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Experimental Cell Research Elsevier

DLX1, a binding protein of beta-catenin, promoted the growth and migration of prostate cancer cells

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Ltd
ISSN
0014-4827
D.O.I.
10.1016/j.yexcr.2018.01.007
Publisher site
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Abstract

Several studies have indicated the involvement of DLX1 in the progression of prostate cancer. However, the functions of DLX1 in the prostate cancer and the underlying molecular mechanism remains largely unknown. In this study, we have shown that DLX1 was up-regulated in the prostate clinical samples. DLX1 promoted the growth, migration and colony formation of prostate cancer cells by activating beta-catenin/TCF signaling. DLX1 interacted with beta-catenin and enhanced the interaction between beta-catenin and TCF4. Taken together, this study demonstrated that DLX1 exerted the oncogenic roles on the prostate cancer by activating beta-catenin/TCF signaling.

Journal

Experimental Cell ResearchElsevier

Published: Feb 1, 2018

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