Article history: Better methods are needed to quantify the distribution of drug among the airways of the lungs of small Received 25 October 2011 animals to facilitate the development of agents that can target speciﬁc airways. Mice were exposed to Received in revised form 13 January 2012 aerosols of aluminum phthalocyanine tetrasulfonic acid (AlPCS) that ranged in concentration and size Accepted 15 January 2012 (0.2–2.8 m). The trachea and lobes were removed and placed between glass slides, and ﬂuorescent Available online 25 January 2012 images were obtained at two different compression thicknesses. The intensity, normalized by the area, exposure time, and thickness, was then plotted as a function of compression thickness, from which the Keywords: concentration and attenuation coefﬁcient were estimated for each lobe and then for each pixel of the Fluorescent imaging image. The latter was then used to generate an image reﬂective of the concentration. The lobe volume, Lungs concentration, and tissue attenuation of AlPCS was consistent among the lobes. The deposition fraction Aerosol increased with decreasing particle size. The network of lines in the concentration image indicated that Aluminum phthalocyanine tetrasulfonic acid connective tissue has a lower concentration. The central airways were clearly evident in the
International Journal of Pharmaceutics – Elsevier
Published: Apr 15, 2012
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